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Drilldown: Medicines

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Medicines > routes : IV (rarely used; same dose) or Oral & onset: Anticoagulant effect at 24-72 hours; full INR effect 5-7 days

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generic:
Warfarin (1)
brand:
Coumadin (discontinued in US but name in common use), Jantoven (1)
classes:
[[:Category:Anticoagulants|Anticoagulant]] (1) · [[:Category:Vitamin_K_antagonists|Vitamin K antagonist]] (1)
mechanism:
None (1)
uses:
'"`UNIQ--vote-0000001B-QINU`"', '"`UNIQ--vote-0000001C-QINU`"', '"`UNIQ--vote-0000001D-QINU`"', '"`UNIQ--vote-0000001E-QINU`"', '"`UNIQ--vote-0000001F-QINU`"' (1)
starting dose:
Typical 5 mg PO daily; 2.5 mg in elderly, low body weight, malnutrition, hepatic dysfunction. Genotype-guided initial dosing per CPIC/IWPC algorithms (CYP2C9, VKORC1, CYP4F2) is one of the most-established PGx applications in current practice (1)
preparations:
1, 2, 2.5, 3, 4, 5, 6, 7.5, 10 mg tablets (color-coded by strength) (1)
fda max:
No fixed maximum; titrated to INR target (1)
routes: (Click arrow to add another value)
onset: (Click arrow to add another value)
duration:
2-5 days after stopping (factor II resynthesis-limited) (1)
halflife:
36-42 hours (R/S enantiomers differ; S-warfarin is 2-5× more potent and cleared by CYP2C9)'"`UNIQ--ref-00000020-QINU`"' (1)
bioavailability:
~100% (oral)'"`UNIQ--ref-00000021-QINU`"' (1)
pregnancy:
'''Contraindicated in pregnancy''' (warfarin embryopathy, fetal hemorrhage) except in mechanical mitral valves where the maternal mortality of alternative agents may exceed fetal risk.'"`UNIQ--ref-00000022-QINU`"' (1)
legal:
[[USLegal:Prescription only|Rx-only]] in US (1)

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