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Medicines > routes : Oral or topical & onset: Caries reduction over months to years of consistent use

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generic:
Sodium fluoride (1)
brand:
Many; topical professional/OTC and Rx oral (1)
classes:
[[:Category:Anticaries_agents|Anticaries agent]] (1) · [[:Category:Trace_elements|Trace element]] (1)
mechanism:
None (1)
uses:
'"`UNIQ--vote-0000131A-QINU`"', '"`UNIQ--vote-0000131B-QINU`"' (1)
starting dose:
OTC dentifrice/rinse 0.05-0.5% fluoride daily; Rx 1.1% sodium fluoride toothpaste/gel daily; supplements (where local water non-fluoridated) age-titrated 0.25-1 mg/d (1)
preparations:
Toothpaste, rinse, gel, varnish (topical); 0.25, 0.5, 1 mg tablets and drops (Rx supplements where appropriate) (1)
fda max:
Topical: per formulation; oral supplement age-dependent (1)
routes: (Click arrow to add another value)
onset: (Click arrow to add another value)
duration:
Hours per topical application (1)
halflife:
~6 hours plasma; long bone retention (1)
bioavailability:
Topical: local effect on enamel; systemic supplementation has high oral bioavailability with skeletal accumulation (1)
pregnancy:
Safe at routine fluoride levels.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
OTC (most dentifrice and rinse) and [[USLegal:Prescription only|Rx-only]] (high-concentration paste/gel, supplements) in US (1)

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