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Drilldown: Medicines

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Medicines > routes : Inhaled or Subcutaneous (abdomen & onset: Glycemic effect within days; full weight effect over months'"`UNIQ--ref-00000301-QINU`"'

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generic:
Tirzepatide (1)
brand:
Mounjaro (T2DM), Zepbound (obesity, OSA) (1)
classes:
[[GLP-1 receptor agonist]] · [[GIP receptor agonist]] · [[Antidiabetic medicines|Antidiabetic]] · [[Anti-obesity medicines|Anti-obesity]] · "Twincretin" (1)
mechanism:
Dual agonist of the [[GIP receptor]] and [[GLP-1 receptor]] ("twincretin"). (1)
uses:
[[Type 2 diabetes mellitus]] · [[Obesity]] · [[Obstructive sleep apnea]] in obesity (1)
starting dose:
2.5 mg SC weekly × 4 wk (non-therapeutic ramp)'"`UNIQ--ref-000002FB-QINU`"' (1)
preparations:
Pre-filled single-dose pen and vial: 2.5 / 5 / 7.5 / 10 / 12.5 / 15 mg'"`UNIQ--ref-000002FC-QINU`"''"`UNIQ--ref-000002FD-QINU`"' (1)
fda max:
15 mg/wk SC'"`UNIQ--ref-000002FE-QINU`"''"`UNIQ--ref-000002FF-QINU`"' (1)
routes: (Click arrow to add another value)
onset: (Click arrow to add another value)
duration:
~7 days (weekly dosing)'"`UNIQ--ref-00000302-QINU`"' (1)
halflife:
~5 days (~120 h)'"`UNIQ--ref-00000303-QINU`"' (1)
bioavailability:
SC ~80%<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
pregnancy:
Avoid. Discontinue ≥1 month pre-conception. May reduce oral contraceptive efficacy during titration.'"`UNIQ--ref-00000304-QINU`"' (1)
legal:
Rx-only;'"`UNIQ--ref-00000305-QINU`"' not a controlled substance (1)
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