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Drilldown: Medicines

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Medicines > routes : Inhaled (DPI or Subcutaneous & onset: LDL reduction ~50-60% from baseline at 1-2 weeks

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generic:
Evolocumab (1)
brand:
Repatha (1)
classes:
[[:Category:Biologics|Biologic]] (1) · [[:Category:Lipid-lowering_agents|Lipid-lowering agent]] (1) · [[:Category:Monoclonal_antibodies|Monoclonal antibody (fully human IgG2)]] (1) · [[:Category:PCSK9_inhibitors|PCSK9 inhibitor]] (1)
mechanism:
None (1)
uses:
'"`UNIQ--vote-0000147C-QINU`"', '"`UNIQ--vote-0000147D-QINU`"', '"`UNIQ--vote-0000147E-QINU`"' (1)
starting dose:
140 mg SC every 2 weeks OR 420 mg SC monthly (3 consecutive injections 5 minutes apart due to volume) (1)
preparations:
140 mg/mL single-use prefilled syringe and SureClick autoinjector; Pushtronex 420 mg/3.5 mL on-body infusor (1)
fda max:
420 mg/month (1)
routes: (Click arrow to add another value)
onset: (Click arrow to add another value)
duration:
2-4 weeks per dose (1)
halflife:
~11-17 days'"`UNIQ--ref-0000147F-QINU`"' (1)
bioavailability:
~72% from SC depot'"`UNIQ--ref-00001480-QINU`"' (1)
pregnancy:
Limited data.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
[[USLegal:Prescription only|Rx-only]] in US (1)

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