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Medicines > routes : IV (rare) or Topical ophthalmic & onset: Migraine effect after 1-3 months of daily use

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generic:
Riboflavin (vitamin B2) (1)
brand:
Many generics/OTC (1)
classes:
[[:Category:B-vitamins|B-vitamin]] (1) · [[:Category:Vitamins|Vitamin]] (1)
mechanism:
'"`UNIQ--vote-0000124C-QINU`"' The 400 mg/d dose for migraine prophylaxis is supported by randomized trials (Schoenen 1998) and remains a low-risk evidence-based supplement option. Characteristic bright-yellow urine fluorescence with high-dose oral supplementation. (1)
uses:
'"`UNIQ--vote-0000124D-QINU`"', '"`UNIQ--vote-0000124E-QINU`"', '"`UNIQ--vote-0000124F-QINU`"' (1)
starting dose:
Migraine prophylaxis: 400 mg PO daily; deficiency replacement 5-30 mg/d (1)
preparations:
25, 50, 100, 250, 400 mg tablets; OTC (1)
fda max:
No strict ceiling for water-soluble vitamin; UL not set (1)
routes: (Click arrow to add another value)
onset: (Click arrow to add another value)
duration:
N/A (1)
halflife:
~1-2 hours plasma (riboflavin itself); FAD/FMN tissue cofactors are continuous (1)
bioavailability:
~50-60% (oral; food enhances) (1)
pregnancy:
Safe at replacement and supplement doses.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
OTC in US (1)

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