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Medicines > routes : IV/IM (Buprenex). Oral swallowed: very low bioavailability due to first-pass; not therapeutic. or Topical & onset: Minutes

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generic:
Chlorhexidine gluconate (CHG) (1)
brand:
Hibiclens, Hibistat, Peridex (dental rinse), ChloraPrep (1)
classes:
[[:Category:Antiseptics|Antiseptic]] (1) · [[:Category:Bisbiguanides|Bisbiguanide]] (1)
mechanism:
None (1)
uses:
'"`UNIQ--vote-00001393-QINU`"', '"`UNIQ--vote-00001394-QINU`"', '"`UNIQ--vote-00001395-QINU`"', '"`UNIQ--vote-00001396-QINU`"', '"`UNIQ--vote-00001397-QINU`"' (1)
starting dose:
Surgical scrub 4% CHG; preop skin prep 2% CHG/70% isopropyl alcohol (ChloraPrep); ICU bathing 2% CHG daily; oral rinse 0.12% 15 mL twice daily for 30 seconds (1)
preparations:
2%, 4% wash; 2% CHG/70% IPA applicators (ChloraPrep); 0.12%, 0.2% oral rinse; impregnated catheter dressings (1)
fda max:
Per formulation (1)
routes: (Click arrow to add another value)
onset: (Click arrow to add another value)
duration:
Persistent activity 6+ hours (residual binding to skin and oral surfaces) (1)
halflife:
Not meaningfully described (negligible systemic absorption from intact skin or oral mucosa)'"`UNIQ--ref-00001398-QINU`"' (1)
bioavailability:
Topical/oral local action with minimal systemic absorption'"`UNIQ--ref-00001399-QINU`"' (1)
pregnancy:
Generally considered safe (minimal systemic absorption).<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
OTC (lower-concentration washes) and [[USLegal:Prescription only|Rx-only]] (Peridex oral rinse, ChloraPrep) in US (1)

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