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Medicines > routes : Subcutaneous or intra-articular & onset: SC: 5-15 minutes; ultra-rapid Lyumjev faster

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generic:
Insulin lispro (1)
brand:
Humalog, Admelog, Lyumjev (1)
classes:
[[:Category:Insulins|Insulin]] (1) · [[:Category:Mealtime_insulins|Mealtime (bolus) insulin]] (1) · [[:Category:Rapid-acting_insulins|Rapid-acting insulin analog]] (1)
mechanism:
'"`UNIQ--vote-00000584-QINU`"' Binds the same insulin receptor as endogenous insulin with comparable mitogenic-to-metabolic ratio. Ultra-rapid formulations (Lyumjev) add treprostinil and citrate to accelerate absorption further'"`UNIQ--ref-00000585-QINU`"'. (1)
uses:
'"`UNIQ--vote-00000586-QINU`"', '"`UNIQ--vote-00000587-QINU`"', '"`UNIQ--vote-00000588-QINU`"' (1)
starting dose:
SC 4-6 units (or 1 unit per 10-15 g carbs) at meals; titrate to postprandial glucose. Typical total daily dose 0.5-1 U/kg/d split between basal and prandial coverage in T1DM (1)
preparations:
100 U/mL (Humalog, Admelog, Lyumjev) vials, pens, cartridges; 200 U/mL Humalog KwikPen (1)
fda max:
Titrated to glucose; no fixed maximum (1)
routes: (Click arrow to add another value)
onset: (Click arrow to add another value)
duration:
3-5 hours (1)
halflife:
~1 hour SC'"`UNIQ--ref-00000589-QINU`"' (1)
bioavailability:
~100% from subcutaneous depot (1)
pregnancy:
Insulin is the preferred glucose-lowering therapy in pregnancy; lispro is widely used.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
[[USLegal:Prescription only|Rx-only]] in US (some OTC formulations exist) (1)

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