Drilldown: Medicines

Phencyclidine (1)

Sernyl (human, withdrawn 1965); Sernylan (veterinary, withdrawn 1978) (1)

[[:Category:Anesthetics|Anesthetic (historical)]] (1) · [[:Category:Arylcyclohexylamines|Arylcyclohexylamine]] (1) · [[:Category:Dissociatives|Dissociative]] (1) · [[:Category:NMDA_receptor_antagonists|NMDA receptor antagonist]] (1) · [[:Category:Sigma-1_receptor_agonists|Sigma-1 receptor agonist]] (1)

None (1)

'"`UNIQ--vote-00000063-QINU`"', '"`UNIQ--vote-00000064-QINU`"' (1)

No current medical indication. Historical anesthetic dose 0.25 mg/kg IV (Sernyl). (1)

Historical: Sernyl 25 mg tablets, 10 mg/mL injection (human); Sernylan 100 mg/mL injection (veterinary). Illicit: white crystalline powder, oily liquid, "dipped" cigarettes ("wet"), tablets. (1)

N/A (no current medical indication) (1)

IM (1) · insufflated (1) · IV (1) · Oral (1) · smoked (1)

None · Hours · 30-60 minutes · 1-2 hours · ~30 min · LDL lowering at 2 weeks, max by 4 weeks · ~1 hour · 15-30 minutes · 15–30 min · 1–2 h · 30–60 min · Antidepressant effect emerges over 1-2 weeks · BP and symptomatic LUTS improvement within 1-2 weeks · BP effect within 1-2 weeks · Clinical improvement within 24-72 hours · Days · Motor improvement over days at therapeutic dose · Over weeks · Postprandial glucose effect within days; HbA1c by 12 weeks · Sleep effect from first dose; antidepressant effect over 1-4 weeks

Other values:

Search

4-8 hours typical; longer at high doses; residual cognitive and perceptual effects up to 48 hours (1)

Highly variable, 7-46 hours (mean ~21 h); lipophilic deposition in fat with delayed re-release contributes to wide range'"`UNIQ--ref-00000065-QINU`"' (1)

~72% oral; ~85% smoked'"`UNIQ--ref-00000066-QINU`"' (1)

None (1)

[[USLegal:DEA Schedule II|Schedule II]] controlled substance in US (rescheduled from Schedule III in 1978). No accepted medical use. UN Convention on Psychotropic Substances Schedule II internationally.'"`UNIQ--ref-00000067-QINU`"' (1)