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Medicines > routes : Topical ophthalmic or intranasal; rectal and IV reported. & onset: Within minutes

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generic:
Ketotifen (1)
brand:
Zaditor, Alaway (ophthalmic, OTC); Zaditen (systemic, outside US) (1)
classes:
[[:Category:H1_receptor_antagonists|Histamine H1 receptor antagonist]] (1) · [[:Category:Mast_cell_stabilizers|Mast cell stabilizer]] (1) · [[:Category:Ophthalmic_antihistamines|Ophthalmic antihistamine]] (1)
mechanism:
'"`UNIQ--vote-00001284-QINU`"' Systemic oral ketotifen (available outside US) has historical use for asthma adjunct therapy via the same dual mechanism, but oral use produces sedation and weight gain — the topical ophthalmic application largely avoids both'"`UNIQ--ref-00001285-QINU`"'. (1)
uses:
'"`UNIQ--vote-00001286-QINU`"' (1)
starting dose:
Ophthalmic 1 drop in each eye every 8-12 hours (1)
preparations:
0.025%, 0.035% ophthalmic solutions (1)
fda max:
1 drop per eye q8-12h (1)
routes: (Click arrow to add another value)
onset: (Click arrow to add another value)
duration:
8-12 hours (1)
halflife:
Not meaningfully described for ophthalmic use'"`UNIQ--ref-00001287-QINU`"' (1)
bioavailability:
Topical with minimal systemic absorption'"`UNIQ--ref-00001288-QINU`"' (1)
pregnancy:
Generally considered safe (minimal systemic exposure).<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
OTC in US (1)

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