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Drilldown: Medicines

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Medicines > starting dose: 2.25 g at bedtime + 2.25 g 2.5–4 h later; titrate weekly to 6–9 g/night total & pregnancy : Category C or Limited data

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generic:
Sodium Oxybate (1)
brand:
Xyrem; Xywav (lower-sodium formulation with Ca/Mg/K salts) (1)
classes:
GABAB Agonist; Endogenous GHB receptor agonist (1)
mechanism:
Agonist at the metabotropic GABAB receptor and the endogenous γ-hydroxybutyrate (GHB) receptor. Produces deep sleep with increased slow-wave architecture, suppression of REM intrusion, and cataplexy reduction. (1)
uses:
'"`UNIQ--vote-00000717-QINU`"', '"`UNIQ--vote-00000718-QINU`"', '"`UNIQ--vote-00000719-QINU`"' (1)
starting dose: (Click arrow to add another value)
preparations:
0.5 g/mL oral solution (1)
fda max:
9 g/night (1)
routes:
Oral (must be taken in bed; effects within minutes) (1)
onset:
15–30 min (fasting) (1)
duration:
~3 h per dose (twice-nightly schedule required) (1)
halflife:
30–60 min (1)
bioavailability:
~25% (high first-pass) (1)
pregnancy: (Click arrow to add another value)
legal:
Schedule III; REMS-restricted (Schedule I if outside the pharmaceutical channel, same molecule as illicit GHB) (1)

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