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Medicines (732)

Medicines > uses

: Acute treatment of migraine with or without aura in adults

or Preventive treatment of migraine in adults (episodic and chronic)

or '"`UNIQ--vote-00000006-QINU`"'

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None (3) · Brugmansia (1) · Bufo alvarius (1) · Mescal Bean (1) · Nutmeg (1) · Phalaris arundinaceae (1)

''Brugmansia'' spp., Angel's trumpet, ''borrachero'', ''toé'' (1) · ''Myristica fragrans''. Mace (the fruit aril) (1) · ''Sophora secundiflora''. Texas mountain laurel, frijolillo (1) · Aimovig (1) · Ajovy (1) · Reed canary grass (1) · Sonoran Desert Toad, Colorado River Toad (1) · Zavzpret (zavegepant) (1)

Animal Medicine (1) · Anti-CGRP ligand monoclonal antibody (1) · Anti-CGRP receptor monoclonal antibody (1) · CGRP receptor antagonist (1) · Daimonica (1) · Empathogenica (1) · Gepant (1) · Phantastica (3) · Plant Med (1) · Plant Medicine (3) · Tropane alkaloid plant (1)

5-MeO-DMT is a potent 5-HT1A agonist (greater than 5-HT2A). Distinct from N,N-DMT in producing a more unitive, less visual, often ego-dissolving experience. (1) · Active alkaloid is cytisine, a nicotinic acetylcholine receptor agonist. NOT a classical 5-HT2A psychedelic. (1) · Active oils are myristicin, elemicin, and safrole, phenethylamine precursors that may be aminated in vivo to MMDA, TMA, and MDA respectively (Shulgin's 'essential amphetamines' hypothesis). (1) · Contains varying amounts of DMT, 5-MeO-DMT, bufotenine, and gramine depending on strain and growing conditions. (1) · Humanized IgG2 monoclonal antibody binding both isoforms of CGRP peptide (1) · Humanized IgG2 monoclonal antibody binding the CGRP receptor (not the peptide); blocks CGRP-mediated vasodilation and nociceptive signaling (1) · Small-molecule CGRP receptor antagonist; intranasal formulation (1) · Tropane alkaloids: scopolamine (dominant), hyoscyamine, atropine. Competitive antagonism at muscarinic acetylcholine receptors. (1)

None (4) · 0.5–1 oz (10–30 g) ground for psychoactive effect; far smaller for culinary use (1) · 10 mg (one spray) intranasally in one nostril (1) · 225 mg SC monthly, or 675 mg SC every 3 months (quarterly) (1) · 70 mg SC monthly; may increase to 140 mg monthly (1)

10 mg/spray nasal solution (1) · 225 mg/1.5 mL prefilled syringe or autoinjector (1) · 70 mg/mL or 140 mg/mL prefilled autoinjector (1) · Acid/base extraction of fresh young grass for tryptamines; combined with an MAOI (1) · Bright red seeds, traditionally ingested or smoked. Highly toxic, narrow margin between active and lethal (1) · Flowers or leaves infused or smoked. Highly variable potency; narrow toxic margin (1) · Ground dried seed (nutmeg) or fruit aril (mace); occasionally infused (1) · Parotid-gland venom expressed onto a glass plate, dried into a shellac-like resin, vaporized and inhaled (1)

None (5) · 10 mg per 24 h (1) · 140 mg/month (1) · 675 mg/quarter (1)

inhalation (1) · Inhalation (vaporized) (1) · Intranasal (1) · Oral (3) · Oral (with MAOI) (1) · Subcutaneous (2)

None (3) · Onset of preventive effect over weeks; some patients respond after first dose (1) · Over weeks (1) · Pain relief reported within 15 min in trials (1) · Seconds (1) · Slow, 2–6 h (1)

None (3) · 12–24 h or longer (1) · Monthly dosing (1) · Monthly or quarterly dosing (1) · ~15 min (1) · ~48 h sustained pain freedom in responders (1)

None (5) · ~28 days (1) · ~31 days (1) · ~6.6 h (1)

None (5) · Not formally established (1) · ~5% intranasal (1) · ~82% SC (1)

None (5) · Limited data; avoid (3)

None (4) · 5-MeO-DMT is Schedule I in US (since 2011); the toad itself is protected in several southwestern states (1) · Rx (3)

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