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Combined display of all available logs of Pharmacopedia. You can narrow down the view by selecting a log type, the username (case-sensitive), or the affected page (also case-sensitive).

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  • 00:32, 20 May 2026 MDElliottMD talk contribs created page Pharmacopedia:Pharmacogenomics sandbox/Phenotype CYP2B6 ultrarapid metabolizer (Sandbox-save pharmacogenomic phenotype page (batch of 25 per Mark 2026-05-19, completing the metabolizer-phenotype set across the 7 enzymes with CPIC phenotype schemes). Definitional satellite of the parent enzyme page: lead defines the phenotype, sections cover genotype basis, population frequency, clinical consequences medicine-by-medicine, and phenocopying where it applies. CPIC/DPWG dosing guidance cited; all PMIDs NCBI-eutils-verified. Final home Phenotype:<NAME> once the namespace is re...)
  • 00:32, 20 May 2026 MDElliottMD talk contribs created page Pharmacopedia:Pharmacogenomics sandbox/Phenotype CYP2B6 rapid metabolizer (Sandbox-save pharmacogenomic phenotype page (batch of 25 per Mark 2026-05-19, completing the metabolizer-phenotype set across the 7 enzymes with CPIC phenotype schemes). Definitional satellite of the parent enzyme page: lead defines the phenotype, sections cover genotype basis, population frequency, clinical consequences medicine-by-medicine, and phenocopying where it applies. CPIC/DPWG dosing guidance cited; all PMIDs NCBI-eutils-verified. Final home Phenotype:<NAME> once the namespace is re...)
  • 00:32, 20 May 2026 MDElliottMD talk contribs created page Pharmacopedia:Pharmacogenomics sandbox/Phenotype CYP2B6 normal metabolizer (Sandbox-save pharmacogenomic phenotype page (batch of 25 per Mark 2026-05-19, completing the metabolizer-phenotype set across the 7 enzymes with CPIC phenotype schemes). Definitional satellite of the parent enzyme page: lead defines the phenotype, sections cover genotype basis, population frequency, clinical consequences medicine-by-medicine, and phenocopying where it applies. CPIC/DPWG dosing guidance cited; all PMIDs NCBI-eutils-verified. Final home Phenotype:<NAME> once the namespace is re...)
  • 00:32, 20 May 2026 MDElliottMD talk contribs created page Pharmacopedia:Pharmacogenomics sandbox/Phenotype CYP2B6 intermediate metabolizer (Sandbox-save pharmacogenomic phenotype page (batch of 25 per Mark 2026-05-19, completing the metabolizer-phenotype set across the 7 enzymes with CPIC phenotype schemes). Definitional satellite of the parent enzyme page: lead defines the phenotype, sections cover genotype basis, population frequency, clinical consequences medicine-by-medicine, and phenocopying where it applies. CPIC/DPWG dosing guidance cited; all PMIDs NCBI-eutils-verified. Final home Phenotype:<NAME> once the namespace is re...)
  • 00:32, 20 May 2026 MDElliottMD talk contribs created page Pharmacopedia:Pharmacogenomics sandbox/Phenotype CYP2B6 poor metabolizer (Sandbox-save pharmacogenomic phenotype page (batch of 25 per Mark 2026-05-19, completing the metabolizer-phenotype set across the 7 enzymes with CPIC phenotype schemes). Definitional satellite of the parent enzyme page: lead defines the phenotype, sections cover genotype basis, population frequency, clinical consequences medicine-by-medicine, and phenocopying where it applies. CPIC/DPWG dosing guidance cited; all PMIDs NCBI-eutils-verified. Final home Phenotype:<NAME> once the namespace is re...)
  • 00:32, 20 May 2026 MDElliottMD talk contribs created page Pharmacopedia:Pharmacogenomics sandbox/Phenotype CYP2C9 normal metabolizer (Sandbox-save pharmacogenomic phenotype page (batch of 25 per Mark 2026-05-19, completing the metabolizer-phenotype set across the 7 enzymes with CPIC phenotype schemes). Definitional satellite of the parent enzyme page: lead defines the phenotype, sections cover genotype basis, population frequency, clinical consequences medicine-by-medicine, and phenocopying where it applies. CPIC/DPWG dosing guidance cited; all PMIDs NCBI-eutils-verified. Final home Phenotype:<NAME> once the namespace is re...)
  • 00:32, 20 May 2026 MDElliottMD talk contribs created page Pharmacopedia:Pharmacogenomics sandbox/Phenotype CYP2C9 intermediate metabolizer (Sandbox-save pharmacogenomic phenotype page (batch of 25 per Mark 2026-05-19, completing the metabolizer-phenotype set across the 7 enzymes with CPIC phenotype schemes). Definitional satellite of the parent enzyme page: lead defines the phenotype, sections cover genotype basis, population frequency, clinical consequences medicine-by-medicine, and phenocopying where it applies. CPIC/DPWG dosing guidance cited; all PMIDs NCBI-eutils-verified. Final home Phenotype:<NAME> once the namespace is re...)
  • 00:32, 20 May 2026 MDElliottMD talk contribs created page Pharmacopedia:Pharmacogenomics sandbox/Phenotype CYP2C9 poor metabolizer (Sandbox-save pharmacogenomic phenotype page (batch of 25 per Mark 2026-05-19, completing the metabolizer-phenotype set across the 7 enzymes with CPIC phenotype schemes). Definitional satellite of the parent enzyme page: lead defines the phenotype, sections cover genotype basis, population frequency, clinical consequences medicine-by-medicine, and phenocopying where it applies. CPIC/DPWG dosing guidance cited; all PMIDs NCBI-eutils-verified. Final home Phenotype:<NAME> once the namespace is re...)
  • 00:32, 20 May 2026 MDElliottMD talk contribs created page Pharmacopedia:Pharmacogenomics sandbox/Phenotype CYP2C19 ultrarapid metabolizer (Sandbox-save pharmacogenomic phenotype page (batch of 25 per Mark 2026-05-19, completing the metabolizer-phenotype set across the 7 enzymes with CPIC phenotype schemes). Definitional satellite of the parent enzyme page: lead defines the phenotype, sections cover genotype basis, population frequency, clinical consequences medicine-by-medicine, and phenocopying where it applies. CPIC/DPWG dosing guidance cited; all PMIDs NCBI-eutils-verified. Final home Phenotype:<NAME> once the namespace is re...)
  • 00:32, 20 May 2026 MDElliottMD talk contribs created page Pharmacopedia:Pharmacogenomics sandbox/Phenotype CYP2C19 rapid metabolizer (Sandbox-save pharmacogenomic phenotype page (batch of 25 per Mark 2026-05-19, completing the metabolizer-phenotype set across the 7 enzymes with CPIC phenotype schemes). Definitional satellite of the parent enzyme page: lead defines the phenotype, sections cover genotype basis, population frequency, clinical consequences medicine-by-medicine, and phenocopying where it applies. CPIC/DPWG dosing guidance cited; all PMIDs NCBI-eutils-verified. Final home Phenotype:<NAME> once the namespace is re...)
  • 00:32, 20 May 2026 MDElliottMD talk contribs created page Pharmacopedia:Pharmacogenomics sandbox/Phenotype CYP2C19 normal metabolizer (Sandbox-save pharmacogenomic phenotype page (batch of 25 per Mark 2026-05-19, completing the metabolizer-phenotype set across the 7 enzymes with CPIC phenotype schemes). Definitional satellite of the parent enzyme page: lead defines the phenotype, sections cover genotype basis, population frequency, clinical consequences medicine-by-medicine, and phenocopying where it applies. CPIC/DPWG dosing guidance cited; all PMIDs NCBI-eutils-verified. Final home Phenotype:<NAME> once the namespace is re...)
  • 00:32, 20 May 2026 MDElliottMD talk contribs created page Pharmacopedia:Pharmacogenomics sandbox/Phenotype CYP2C19 intermediate metabolizer (Sandbox-save pharmacogenomic phenotype page (batch of 25 per Mark 2026-05-19, completing the metabolizer-phenotype set across the 7 enzymes with CPIC phenotype schemes). Definitional satellite of the parent enzyme page: lead defines the phenotype, sections cover genotype basis, population frequency, clinical consequences medicine-by-medicine, and phenocopying where it applies. CPIC/DPWG dosing guidance cited; all PMIDs NCBI-eutils-verified. Final home Phenotype:<NAME> once the namespace is re...)
  • 00:32, 20 May 2026 MDElliottMD talk contribs created page Pharmacopedia:Pharmacogenomics sandbox/Phenotype CYP2C19 poor metabolizer (Sandbox-save pharmacogenomic phenotype page (batch of 25 per Mark 2026-05-19, completing the metabolizer-phenotype set across the 7 enzymes with CPIC phenotype schemes). Definitional satellite of the parent enzyme page: lead defines the phenotype, sections cover genotype basis, population frequency, clinical consequences medicine-by-medicine, and phenocopying where it applies. CPIC/DPWG dosing guidance cited; all PMIDs NCBI-eutils-verified. Final home Phenotype:<NAME> once the namespace is re...)
  • 00:32, 20 May 2026 MDElliottMD talk contribs created page Pharmacopedia:Pharmacogenomics sandbox/Phenotype CYP2D6 ultrarapid metabolizer (Sandbox-save pharmacogenomic phenotype page (batch of 25 per Mark 2026-05-19, completing the metabolizer-phenotype set across the 7 enzymes with CPIC phenotype schemes). Definitional satellite of the parent enzyme page: lead defines the phenotype, sections cover genotype basis, population frequency, clinical consequences medicine-by-medicine, and phenocopying where it applies. CPIC/DPWG dosing guidance cited; all PMIDs NCBI-eutils-verified. Final home Phenotype:<NAME> once the namespace is re...)
  • 00:32, 20 May 2026 MDElliottMD talk contribs created page Pharmacopedia:Pharmacogenomics sandbox/Phenotype CYP2D6 normal metabolizer (Sandbox-save pharmacogenomic phenotype page (batch of 25 per Mark 2026-05-19, completing the metabolizer-phenotype set across the 7 enzymes with CPIC phenotype schemes). Definitional satellite of the parent enzyme page: lead defines the phenotype, sections cover genotype basis, population frequency, clinical consequences medicine-by-medicine, and phenocopying where it applies. CPIC/DPWG dosing guidance cited; all PMIDs NCBI-eutils-verified. Final home Phenotype:<NAME> once the namespace is re...)
  • 00:32, 20 May 2026 MDElliottMD talk contribs created page Pharmacopedia:Pharmacogenomics sandbox/Phenotype CYP2D6 intermediate metabolizer (Sandbox-save pharmacogenomic phenotype page (batch of 25 per Mark 2026-05-19, completing the metabolizer-phenotype set across the 7 enzymes with CPIC phenotype schemes). Definitional satellite of the parent enzyme page: lead defines the phenotype, sections cover genotype basis, population frequency, clinical consequences medicine-by-medicine, and phenocopying where it applies. CPIC/DPWG dosing guidance cited; all PMIDs NCBI-eutils-verified. Final home Phenotype:<NAME> once the namespace is re...)
  • 23:28, 19 May 2026 MDElliottMD talk contribs created page Pharmacopedia:Pharmacogenomics sandbox/Phenotype CYP2D6 poor metabolizer (Sandbox-save CYP2D6 poor metabolizer phenotype page as the template exemplar for the pharmacogenomic phenotype subpage set (26 pages across 7 enzymes with CPIC phenotype schemes). Definitional satellite page of Enzyme:CYP2D6: lead defines the phenotype + the two-directional clinical principle (activation case vs clearance case); sections for genotype basis, population frequency, clinical consequences, phenocopying. CPIC opioid guideline cited PMID 33387367 (verified). Deliberate deviation fro...)
  • 23:27, 19 May 2026 MDElliottMD talk contribs created page Category:CuratedCategoryPage (Create CuratedCategoryPage maintenance marker (hidden category) per canonical category-page structure)
  • 22:39, 19 May 2026 MDElliottMD talk contribs created page Category:Drug-metabolizing enzymes (Create Category:Drug-metabolizing enzymes: curated index of the 11 enzyme entity pages (8 CYPs + UGT1A1 + TPMT + NUDT15) at their canonical Pharmacopedia: sandbox location, grouped by enzyme family, with scope notes distinguishing enzymes from transporters and non-enzyme variant loci. Parent Category:Pharmacogenomics.)
  • 22:39, 19 May 2026 MDElliottMD talk contribs created page Pharmacopedia:Pharmacogenomics sandbox/Enzyme NUDT15 (Consolidate enzyme entity page to canonical Pharmacopedia: sandbox location per Mark 2026-05-19. Full retrofitted version: history-first spine, collapsible-sortable substrate table, comprehensive-tables pointer, all PMIDs NCBI-eutils-verified, zero em-dashes. For CYP2D6/CYP3A4/CYP2C19 this replaces the earlier pre-retrofit draft with the full version; for the other 8 enzymes this is the first save at the canonical location. Resolves a cross-session sandbox-location duplication: the User:MDEll...)
  • 22:39, 19 May 2026 MDElliottMD talk contribs created page Pharmacopedia:Pharmacogenomics sandbox/Enzyme TPMT (Consolidate enzyme entity page to canonical Pharmacopedia: sandbox location per Mark 2026-05-19. Full retrofitted version: history-first spine, collapsible-sortable substrate table, comprehensive-tables pointer, all PMIDs NCBI-eutils-verified, zero em-dashes. For CYP2D6/CYP3A4/CYP2C19 this replaces the earlier pre-retrofit draft with the full version; for the other 8 enzymes this is the first save at the canonical location. Resolves a cross-session sandbox-location duplication: the User:MDEll...)
  • 22:39, 19 May 2026 MDElliottMD talk contribs created page Pharmacopedia:Pharmacogenomics sandbox/Enzyme UGT1A1 (Consolidate enzyme entity page to canonical Pharmacopedia: sandbox location per Mark 2026-05-19. Full retrofitted version: history-first spine, collapsible-sortable substrate table, comprehensive-tables pointer, all PMIDs NCBI-eutils-verified, zero em-dashes. For CYP2D6/CYP3A4/CYP2C19 this replaces the earlier pre-retrofit draft with the full version; for the other 8 enzymes this is the first save at the canonical location. Resolves a cross-session sandbox-location duplication: the User:MDEll...)
  • 22:39, 19 May 2026 MDElliottMD talk contribs created page Pharmacopedia:Pharmacogenomics sandbox/Enzyme CYP2E1 (Consolidate enzyme entity page to canonical Pharmacopedia: sandbox location per Mark 2026-05-19. Full retrofitted version: history-first spine, collapsible-sortable substrate table, comprehensive-tables pointer, all PMIDs NCBI-eutils-verified, zero em-dashes. For CYP2D6/CYP3A4/CYP2C19 this replaces the earlier pre-retrofit draft with the full version; for the other 8 enzymes this is the first save at the canonical location. Resolves a cross-session sandbox-location duplication: the User:MDEll...)
  • 22:39, 19 May 2026 MDElliottMD talk contribs created page Pharmacopedia:Pharmacogenomics sandbox/Enzyme CYP2C9 (Consolidate enzyme entity page to canonical Pharmacopedia: sandbox location per Mark 2026-05-19. Full retrofitted version: history-first spine, collapsible-sortable substrate table, comprehensive-tables pointer, all PMIDs NCBI-eutils-verified, zero em-dashes. For CYP2D6/CYP3A4/CYP2C19 this replaces the earlier pre-retrofit draft with the full version; for the other 8 enzymes this is the first save at the canonical location. Resolves a cross-session sandbox-location duplication: the User:MDEll...)
  • 22:39, 19 May 2026 MDElliottMD talk contribs created page Pharmacopedia:Pharmacogenomics sandbox/Enzyme CYP2C8 (Consolidate enzyme entity page to canonical Pharmacopedia: sandbox location per Mark 2026-05-19. Full retrofitted version: history-first spine, collapsible-sortable substrate table, comprehensive-tables pointer, all PMIDs NCBI-eutils-verified, zero em-dashes. For CYP2D6/CYP3A4/CYP2C19 this replaces the earlier pre-retrofit draft with the full version; for the other 8 enzymes this is the first save at the canonical location. Resolves a cross-session sandbox-location duplication: the User:MDEll...)
  • 22:39, 19 May 2026 MDElliottMD talk contribs created page Pharmacopedia:Pharmacogenomics sandbox/Enzyme CYP2B6 (Consolidate enzyme entity page to canonical Pharmacopedia: sandbox location per Mark 2026-05-19. Full retrofitted version: history-first spine, collapsible-sortable substrate table, comprehensive-tables pointer, all PMIDs NCBI-eutils-verified, zero em-dashes. For CYP2D6/CYP3A4/CYP2C19 this replaces the earlier pre-retrofit draft with the full version; for the other 8 enzymes this is the first save at the canonical location. Resolves a cross-session sandbox-location duplication: the User:MDEll...)
  • 22:39, 19 May 2026 MDElliottMD talk contribs created page Pharmacopedia:Pharmacogenomics sandbox/Enzyme CYP1A2 (Consolidate enzyme entity page to canonical Pharmacopedia: sandbox location per Mark 2026-05-19. Full retrofitted version: history-first spine, collapsible-sortable substrate table, comprehensive-tables pointer, all PMIDs NCBI-eutils-verified, zero em-dashes. For CYP2D6/CYP3A4/CYP2C19 this replaces the earlier pre-retrofit draft with the full version; for the other 8 enzymes this is the first save at the canonical location. Resolves a cross-session sandbox-location duplication: the User:MDEll...)
  • 22:11, 19 May 2026 MDElliottMD talk contribs created page User:MDElliottMD/Sandbox/CYP2B6 (Sandbox-save CYP2B6 enzyme entity page (9th pharmacogenomics enzyme page). History-first spine: the rehabilitation of a long-neglected enzyme - Lang/Klein/Zanger Dr. Margarete Fischer-Bosch Institute Stuttgart 2001 polymorphism survey PMID 11470993. 16-row collapsible-sortable substrate table (efavirenz canonical, bupropion probe, methadone, cyclophosphamide/ifosfamide bioactivation, ketamine, others). Full PM/IM/NM/RM/UM phenotype classification per CPIC efavirenz guideline. Major variant *6...)
  • 22:03, 19 May 2026 MDElliottMD talk contribs created page User:MDElliottMD/Sandbox/CYP1A2 (Sandbox-save CYP1A2 enzyme entity page (8th pharmacogenomics enzyme page). History-first spine: Anthony Conney enzyme-induction research (Hoffmann-La Roche, Nutley NJ), 1982 Clowes Memorial Lecture PMID 6814745, AhR induction mechanism. 28-row collapsible-sortable substrate table (clozapine/olanzapine/theophylline/tizanidine headline substrates; caffeine probe; antidepressants, triptans, others). Phenotype section: honest no-PM/IM/NM-bedside-classification (like CYP3A4); variability dominated...)
  • 21:44, 19 May 2026 MDElliottMD talk contribs created page User:MDElliottMD/Sandbox/NUDT15 (Sandbox-save NUDT15 enzyme entity page (7th pharmacogenomics enzyme page, parallel to TPMT). History-first spine: Asan Medical Center Seoul 2014 GWAS in Korean IBD cohort discovering NUDT15 rs116855232 Arg139Cys, Yang 2014 Nat Genet PMID 25108385; Moriyama 2016 Nat Genet mechanism (St. Jude) PMID 26878724; Yang 2015 JCO ALL extension PMID 25624441; Moriyama 2017 Blood diverse-ancestry alleles PMID 28659275; Relling 2019 CPIC TPMT+NUDT15 PMID 30447069; PharmGKB Whirl-Carrillo 2021 PMID 3421602...)
  • 21:35, 19 May 2026 MDElliottMD talk contribs created page User:MDElliottMD/Sandbox/TPMT (Sandbox-save TPMT enzyme entity page (6th pharmacogenomics enzyme page). History-first spine: Weinshilboum & Sladek 1980 Mayo Clinic bimodal-distribution discovery PMID 7191632, one of the foundational pharmacogenetics demonstrations. Lennard 1989 azathioprine-toxicity link PMID 2758725; Krynetski 1995 PNAS TPMT*2 molecular variant PMID 7862671; Loennechen 1998 TPMT*3C PMID 9695718; Relling 2019 CPIC TPMT+NUDT15 thiopurine dosing PMID 30447069. NUDT15 cross-reference section cites Yang 2014 N...)
  • 21:09, 19 May 2026 MDElliottMD talk contribs created page User:MDElliottMD/Sandbox/UGT1A1 (Sandbox-save UGT1A1 enzyme entity page (5th of 10 pharmacogenomics enzyme pages). History-first spine: Gilbert 1901 Paris + Bosma 1995 NEJM Amsterdam closure (UGT1A1*28 promoter TA-repeat discovery). Two CPIC/DPWG guidelines cited: Gammal 2016 CPIC atazanavir PMID 26417955, Hulshof 2023 DPWG irinotecan PMID 36443464. Plus mechanistic refs Iyer 1998 JCI PMID 9466980 (UGT1A1 + SN-38), Innocenti 2004 JCO PMID 15007088 (irinotecan + UGT1A1*28 + neutropenia). Plus Tukey & Strassburg 2000 Annu Rev...)
  • 20:44, 19 May 2026 MDElliottMD talk contribs created page User:MDElliottMD/Sandbox/CYP2C19 (Retrofit CYP2C19 sandbox per Mark 2026-05-19 Option C decision: collapsible-sortable near-complete substrate table (32 rows: PPIs, SSRIs, clopidogrel/proguanil activation, voriconazole, diazepam, mephenytoin probe, carisoprodol, others; tier-tagged major/moderate/minor/partial; activation reactions flagged for clopidogrel and proguanil). Plus Comprehensive substrate and interaction tables pointer section. NOTE: also restored three CPIC-guideline ref definitions (cpic-clopidogrel-2022 PMID 350...)
  • 20:44, 19 May 2026 MDElliottMD talk contribs created page User:MDElliottMD/Sandbox/CYP3A4 (Retrofit CYP3A4 sandbox per Mark 2026-05-19 Option C decision: collapsible-sortable near-complete substrate table (57 rows: benzodiazepines, calcium channel blockers, statins, immunosuppressants, anti-cancer, macrolides, HIV protease inhibitors, DOACs, opioids, antifungals, PDE5 inhibitors, antihistamines, endogenous steroids, others; tier-tagged major/moderate/minor/partial). Plus Comprehensive substrate and interaction tables pointer section naming Flockhart Indiana University, FDA Drug Dev...)
  • 20:44, 19 May 2026 MDElliottMD talk contribs created page User:MDElliottMD/Sandbox/CYP2D6 (Retrofit CYP2D6 sandbox per Mark 2026-05-19 Option C decision: collapsible-sortable near-complete substrate table (49 rows: opioid prodrugs, TCAs, SSRIs/SNRIs, antipsychotics, beta blockers, antiarrhythmics, antiemetics, tamoxifen, atomoxetine, perhexiline, antihistamines, others; tier-tagged major/moderate/minor/partial; activation reactions flagged for codeine/tramadol/risperidone/tamoxifen/venlafaxine). Plus Comprehensive substrate and interaction tables pointer section naming Flockhart In...)
  • 19:31, 19 May 2026 MDElliottMD talk contribs created page User:MDElliottMD/Sandbox/CYP2C9 (Sandbox-save CYP2C9 enzyme entity page (4th of 10 pharmacogenomics enzyme pages). History-first spine: Rettie 1992 Seattle / S-warfarin / CYP2C9. Three CPIC guidelines cited: warfarin 2017 PMID 28198005, phenytoin 2020 PMID 32779747, NSAIDs 2020 PMID 32189324. Plus Rettie 1992 PMID 1581537, Sullivan-Klose 1996 PMID 8873220 (CYP2C9*3 / tolbutamide), Aithal 1999 PMID 10073515 (Lancet warfarin dose / bleeding). All 6 PMIDs NCBI-eutils-verified. Final home Enzyme:CYP2C9 once namespace registered.)
  • 19:20, 19 May 2026 MDElliottMD talk contribs created page Category:Plant (Revise Category:Plant root page per interface-claude 2026-05-20 spec: (A) split 10 -> 13 subcategories (Psychedelic / Entheogenic split; Sedative (botanical) / Anxiolytic (botanical) split; Toxic plants / Historical plants split); (B) Functional mushrooms renamed to Medicinal mushroom per ethnomycology convention; (C) Pendell axis section locked with full 11-class wikitable and volume display labels (Inebriant/Stimulant/Visionary); (D) adaptogen EMA HMPC 2008 Reflection Paper EMEA/HMPC/102655...)
  • 19:20, 19 May 2026 MDElliottMD talk contribs created page Category:Pharmaceutical (Revise Category:Pharmaceutical root page per interface-claude 2026-05-20 spec: (A) inline citations added to History section (Huxtable 2001 PMID 14993340 for Sertürner morphine; Sneader 2005 book for Pelletier-Caventou alkaloid sweep, Mein atropine, Niemann cocaine, Bayer barbital; Sneader 2000 BMJ PMID 11124191 for aspirin; Gensini 2007 J Infect PMID 16567000 for Ehrlich/Salvarsan); (B) expanded class subcategories list grouped by therapeutic domain with explicit to-be-created flags for Anti...)
  • 18:00, 19 May 2026 MDElliottMD talk contribs created page Category:Metaphysica (Create Category:Metaphysica: Pendell's first-volume class for substances offering intimations on the nature of things (nitrous oxide as anchor; Leonotis leonurus + Hedera helix as minor members). History-first spine led by Humphry Davy 1799 Bristol + William James 1882. Parents: Category:Pharmaceutical + Category:Plant per multi-membership rule. Plus MedCategory + MedCategoryFull tags. 4 cited refs: Pendell Poeia 1995, Davy 1800 primary, James 1882 Mind primary, Garakani 2016 Am J Addict PMID...)
  • 18:00, 19 May 2026 MDElliottMD talk contribs created page Category:Inebriantia (Create Category:Inebriantia: Pendell's first-volume class for substances that produce drunkenness (alcohol/beer/distilled spirits/ether/volatile inhalants). History-first spine + members + mechanisms + safety. Parents: Category:Pharmaceutical + Category:Plant per multi-membership rule (ether is pharma; alcohol straddles). Plus MedCategory + MedCategoryFull marker tags. 4 cited refs: Pendell Poeia 1995, McGovern 2004 PNAS PMID 15590771, McGovern 2017 PNAS PMID 29133421, Berling 2023 Addiction...)
  • 16:43, 19 May 2026 MDElliottMD talk contribs created page Pharmacopedia:Pharmacogenomics sandbox/Enzyme CYP2C19 (Pharmacogenomics entity page: CYP2C19. Three CPIC Level A indications (clopidogrel + PPIs + SSRIs/voriconazole). Five-phenotype classification PM/IM/NM/RM/UM driven by *2 / *3 / *17 alleles; ancestry-frequency variation called out. Clopidogrel prodrug-activation story; PPI dose-by-phenotype; SSRI QT-prolongation in PMs. 9 inline cites across 4 PMID-verified refs: Wilkinson 2005 NEJM (PMID 15917386), Lee/Luzum 2022 CPIC clopidogrel (PMID 35034351), Lima 2021 CPIC PPI (PMID 32770672), Bousman 2...)
  • 16:32, 19 May 2026 MDElliottMD talk contribs created page Pharmacopedia:Pharmacogenomics sandbox/Enzyme CYP3A4 (Pharmacogenomics entity page: CYP3A4. Second of 10 canonical enzyme pages in Phase 1 (after CYP2D6 yesterday). Sandboxed under Pharmacopedia:Pharmacogenomics sandbox/ until interface-claude registers the Enzyme: namespace; will move to Enzyme:CYP3A4 thereafter. Covers tissue distribution (gut + liver), substrate spectrum (~50% of all medicines), inhibitor strength/kinetic-class taxonomy (grapefruit mechanism-based story), inducer pharmacology (rifampin PXR/CAR), CYP3A5*3 cross-reference, summ...)
  • 07:10, 19 May 2026 MDElliottMD talk contribs created page File:Cannabis sativa plant.JPG (== Summary == Cannabis sativa, Chmee2 2010, CC BY-SA 3.0 + GFDL 1.2+, via Wikimedia Commons. Quality image. Original at https://commons.wikimedia.org/wiki/File:Cannabis_sativa_plant_(4).JPG)
  • 07:10, 19 May 2026 MDElliottMD talk contribs uploaded File:Cannabis sativa plant.JPG (== Summary == Cannabis sativa, Chmee2 2010, CC BY-SA 3.0 + GFDL 1.2+, via Wikimedia Commons. Quality image. Original at https://commons.wikimedia.org/wiki/File:Cannabis_sativa_plant_(4).JPG) Tag: Server-side upload
  • 07:01, 19 May 2026 MDElliottMD talk contribs created page Story:My first arrest (Created from Quick Add)
  • 06:22, 19 May 2026 MDElliottMD talk contribs created page THCV (Create Tetrahydrocannabivarin (THCV) medicine stub: minor phytocannabinoid, propyl analogue of THC, biphasic CB1 activity (low-dose neutral antagonist, high-dose partial agonist), investigational interest in appetite suppression and type 2 diabetes. Cites Russo 2011 (PMID 21749363).)
  • 06:22, 19 May 2026 MDElliottMD talk contribs created page CBG (Create Cannabigerol (CBG) medicine stub: minor phytocannabinoid, biosynthetic precursor from CBGA to THCA/CBDA/CBCA, non-psychoactive, multiple non-CB pharmacology targets. Cites Russo 2011 (PMID 21749363).)
  • 06:22, 19 May 2026 MDElliottMD talk contribs created page CBN (Create Cannabinol (CBN) medicine stub: minor phytocannabinoid, THC oxidation product, weak CB1 partial agonist, popularly framed as a sleep cannabinoid with sparse controlled evidence. Cites Russo 2011 entourage-effect review (PMID 21749363).)
  • 06:22, 19 May 2026 MDElliottMD talk contribs created page CBD (Create CBD as redirect to Cannabidiol; tagged into Category:Medicines + Category:Cannabinoids per the alternate-name pattern (cf. Heroin -> Diacetylmorphine). Closes the CBD redlink that the Cannabis exemplar page surfaced.) Tag: New redirect
  • 06:18, 19 May 2026 MDElliottMD talk contribs created page Template:PlantMedTemplate (Create Template:PlantMedTemplate: sibling of MedTemplate, structured for whole-plant entities. Plant-identity fields (binomial, family, common_names, native_range, cultivars, parts_used, cultivation) + plant-specific narrative H2 sections (Botany, Traditional uses, Preparations, Active constituents, Prohibition history). Per-preparation PK lives in Preparations section rather than infobox. interactionsummary field per the pharmacogenomics design. Same H2 anchor convention as MedTemplate.)
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