Hydrocodone
Checked
Opioid, Analgesic
Hydrocodone
Vicodin
Experience
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Effects
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Interactions
Pharmacogenomic + mechanism interactions
Pharmacogenomic guideline recommendationsCPIC and Dutch Pharmacogenetics Working Group clinical guidelines
CPIC rec 8094288 [Strong]: Use hydrocodone label recommended age- or weight-specific dosing. CPIC pair-level B (CYP2D6, OPRM1, COMT, and Opioids) [PMID 33387367]
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Clinical relevance: does this interaction matter in practice?trivialcritical
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CPIC rec 8094284 [Optional]: Use hydrocodone label recommended age- or weight-specific dosing. If no response and opioid use is warranted, consider non-codeine or non-tramadol opioid. CPIC pair-level B (CYP2D6, OPRM1, COMT, and Opioids) [PMID 33387367]
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CPIC rec 8094293 [Optional]: Use hydrocodone label recommended age- or weight-specific dosing. If no response and opioid use is warranted, consider non-codeine and non-tramadol opioid. CPIC pair-level B (CYP2D6, OPRM1, COMT, and Opioids) [PMID 33387367]
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CPIC rec 8094298 [No Recommendation]: No recommendation for hydrocodone therapy because of minimal evidence regarding adverse events or analgesia. CPIC pair-level B (CYP2D6, OPRM1, COMT, and Opioids) [PMID 33387367]
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Clinical relevance: does this interaction matter in practice?trivialcritical
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Your own experience with this combination:
Experience (1 a little, 5 a lot)
Outcome (-100 worst, +100 best)
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Summary
Classes
Opioid, Analgesic
Common uses
Pharmacy
Pharmacology
Purported mechanism
Mu-opioid receptor agonist