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Drilldown: Medicines

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Medicines > classes : Analgesic or Anticonvulsant or Antidepressant

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generic:
Codeine (2)
brand:
None (6)
classes: (Click arrow to add another value)
mechanism:
Mu-opioid receptor agonist (4) · Irreversible non-selective MAO inhibitor (3) · Potent mu-opioid receptor agonist (3) · Selective norepinephrine reuptake inhibitor (3) · Serotonin and norepinephrine reuptake inhibitor (3) · Serotonin–norepinephrine reuptake inhibitor (2) · Sodium channel blocker (2)
uses:
None (52) · Depression, anxiety, neuropathic pain, fibromyalgia, chronic musculoskeletal pain (1) · Mild to moderate pain; cough suppression (low-dose). (1)
starting dose:
None (52) · 25 mg (1) · Adult: 15–60 mg every 4 hours as needed. (1)
preparations:
None (52) · 25 mg, 50 mg, 100 mg tablets; oral concentrate 20 mg/mL (1) · Tablet (15, 30, 60 mg); oral solution; combination products (with [[Acetaminophen|acetaminophen]] or ibuprofen). (1)
fda max:
None (52) · 200 mg/d (1) · 360 mg/day (1)
routes:
None (51) · Oral (2) · PO (only formulation marketed in the US). (1)
onset:
None (51) · 30–60 min (PO) (1) · Anxiolysis classically 3-4 weeks, continuing improvement to 8-12 weeks (1) · Mood: 2–4 weeks. Pain: often within 1–2 weeks. (1)
duration:
None (51) · 4–6 hours (1) · Chronic daily dosing (1) · Long (1)
halflife:
None (51) · 2.5–3 hours (1) · ~12 hours (1) · ~26 h (sertraline; range 13-45 h, longer in females); ~62-104 h (N-desmethylsertraline, weakly active) (1)
bioavailability:
None (51) · Absolute bioavailability not precisely characterized; food modestly increases exposure (1) · ~50% (highly variable) (1) · ~50% (variable, CYP2D6-dependent for analgesic effect). (1)
pregnancy:
None (51) · Avoid; risk of neonatal opioid withdrawal with chronic use; UM-mother breastfeeding contraindicated. (1) · Category C (1) · Category C'"`UNIQ--ref-0000008F-QINU`"' (1)
legal:
None (51) · Rx-only (1) · Rx-only in US (1) · US Schedule II (single-entity); Schedule III–V (combination products by content). (1)

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