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Medicines > classes : Analgesic or Anticonvulsant or Migraine medicine

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generic:
Codeine (2)
brand:
None (5)
classes: (Click arrow to add another value)
mechanism:
5-HT1B/1D agonist (4) · 5-HT1B/1D agonist; alpha-adrenergic agonist (2) · 5-HT1B/1D agonist; long half-life (1) · 5-HT1F receptor agonist (1) · AMPA receptor antagonist (1) · CGRP receptor antagonist (2) · GABA enhancer; sodium channel blocker; histone deacetylase inhibitor (1) · GABA reuptake inhibitor (GAT-1 blocker) (1) · GABAA positive allosteric modulator (1) · GABAA positive allosteric modulator; lactate dehydrogenase inhibitor (1) · GABAA potentiator and direct activator (1) · Irreversible GABA-T inhibitor (1) · Kappa agonist; mu antagonist (1) · Kappa agonist; mu partial agonist (1) · Kappa agonist; mu partial agonist/antagonist (1) · Mu-opioid agonist; norepinephrine reuptake inhibitor (1) · Mu-opioid receptor agonist (4) · Mu-opioid receptor agonist; prodrug (metabolized to morphine) (1) · Mu-opioid receptor agonist; sodium channel blocker (1) · Mu/kappa/delta agonist; NMDA antagonist (1) · Multiple mechanisms; GPR55 antagonist; TRPV1 agonist (1) · NMDA antagonist; GABAA potentiator (1) · Phosphodiesterase inhibitor; calcium channel blocker (1) · Potent mu-opioid receptor agonist (3) · Prodrug of phenytoin; sodium channel blocker (1) · Prodrug; converted to [[Morphine|morphine]] by [[Enzyme:CYP2D6|CYP2D6]] for analgesic action. (1) · Serotonin releaser; sigma-1 agonist (1) · Slow-inactivation sodium channel enhancer; CRMP-2 ligand (1) · Sodium channel blocker (2) · Sodium channel blocker; GABAA positive allosteric modulator (1) · Sodium channel modulator (1) · Sodium/T-type calcium channel blocker; carbonic anhydrase inhibitor (1) · SV2A ligand (higher affinity than levetiracetam) (1) · T-type calcium channel blocker (1)
uses:
None (44) · Mild to moderate pain; cough suppression (low-dose). (1)
starting dose:
None (44) · Adult: 15–60 mg every 4 hours as needed. (1)
preparations:
None (44) · Tablet (15, 30, 60 mg); oral solution; combination products (with [[Acetaminophen|acetaminophen]] or ibuprofen). (1)
fda max:
None (44) · 360 mg/day (1)
routes:
None (44) · PO (only formulation marketed in the US). (1)
onset:
None (44) · 30–60 min (PO) (1)
duration:
None (44) · 4–6 hours (1)
halflife:
None (44) · 2.5–3 hours (1)
bioavailability:
None (44) · ~50% (variable, CYP2D6-dependent for analgesic effect). (1)
pregnancy:
None (44) · Avoid; risk of neonatal opioid withdrawal with chronic use; UM-mother breastfeeding contraindicated. (1)
legal:
None (44) · US Schedule II (single-entity); Schedule III–V (combination products by content). (1)

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