Drilldown: Medicines

Codeine (2)

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None (14) · (multiple, generic dominant) (1) · Dalmane (1) · Darvon (1) · Demerol (1) · Dilaudid (1) · Doral (1) · Drisdol, Calcidol; also many OTC preparations (1) · Duragesic (1) · Halcion (1) · Lexotan (1) · Librium (1) · Many OTC; Rx 50,000 IU also available (1) · Mogadon (1) · Nubain (1) · Nucynta (1) · Onfi (1) · Opana (1) · ProSom (1) · Restoril (1) · Rohypnol (1) · Serax (1) · Stadol (1) · Talwin (1) · Tranxene (1) · Versed (1) · Vicodin (1) · Xanax (1)

Research material · Classic Psychedelic · Stimulant · Opioid · Sedative-Hypnotic · Phenethylamine · Tryptamine · Benzodiazepine · Botanical · [[:Category:Antihypertensives|Antihypertensive]] · Dissociative · Anticonvulsant · Antidepressant · Plant Medicine · Analgesic · Antiparkinsonian · Antipsychotic · Empathogen · Neuroleptic · Cathinone

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Extremely potent GABAA positive allosteric modulator (1) · GABA-A positive allosteric modulator'"`UNIQ--ref-00000067-QINU`"' '"`UNIQ--vote-00000068-QINU`"' (1) · GABAA positive allosteric modulator (18) · GABAA positive allosteric modulator; low sedation (1) · GABAA positive allosteric modulator; prodrug of desmethyldiazepam (1) · GABAA positive allosteric modulator; very long half-life (1) · Kappa agonist; mu antagonist (1) · Kappa agonist; mu partial agonist (1) · Kappa agonist; mu partial agonist/antagonist (1) · Mu-opioid agonist; norepinephrine reuptake inhibitor (1) · Mu-opioid receptor agonist (4) · Mu-opioid receptor agonist; prodrug (metabolized to morphine) (1) · Mu-opioid receptor agonist; sodium channel blocker (1) · Mu/kappa/delta agonist; NMDA antagonist (1) · Phosphodiesterase inhibitor; calcium channel blocker (1) · Potent mu-opioid receptor agonist (3) · Prodrug; converted to [[Morphine|morphine]] by [[Enzyme:CYP2D6|CYP2D6]] for analgesic action. (1) · '"`UNIQ--vote-0000032A-QINU`"' D3 (cholecalciferol) is more potent at raising serum 25(OH)D per dose; D2 remains widely prescribed in the US Rx 50,000 IU formulation'"`UNIQ--ref-0000032B-QINU`"'. (1) · '"`UNIQ--vote-0000042C-QINU`"' D3 is more potent than D2 at raising and sustaining serum 25(OH)D per dose, and is the more common OTC formulation; D2 remains the dominant Rx 50,000 IU formulation in the US for historical reasons. (1)

None (37) · Mild to moderate pain; cough suppression (low-dose). (1) · '"`UNIQ--vote-00000069-QINU`"', '"`UNIQ--vote-0000006A-QINU`"', '"`UNIQ--vote-0000006B-QINU`"' (1) · '"`UNIQ--vote-0000032C-QINU`"', '"`UNIQ--vote-0000032D-QINU`"', '"`UNIQ--vote-0000032E-QINU`"', '"`UNIQ--vote-0000032F-QINU`"' (1) · '"`UNIQ--vote-0000042D-QINU`"', '"`UNIQ--vote-0000042E-QINU`"', '"`UNIQ--vote-0000042F-QINU`"', '"`UNIQ--vote-00000430-QINU`"' (1)

None (37) · 0.25 mg (1) · Adult: 15–60 mg every 4 hours as needed. (1) · Deficiency: 50,000 IU PO weekly for 8-12 weeks, then maintenance 800-2,000 IU/day; maintenance OTC dosing typically 800-2,000 IU/d (1) · Maintenance 800-2,000 IU PO daily; deficiency replacement 50,000 IU PO weekly for 8-12 weeks then maintenance, or equivalent daily dosing 5,000-10,000 IU/d (1)

None (37) · 0.25 mg, 0.5 mg, 1 mg, 2 mg tablets (immediate-release and orally disintegrating); 0.5 mg, 1 mg, 2 mg, 3 mg extended-release tablets; 1 mg/mL oral concentrate (1) · 50,000 IU capsules (Rx); 8,000 IU/mL oral solution (Rx); 400-5,000 IU OTC tablets and softgels (1) · OTC 400, 1,000, 2,000, 5,000 IU softgels and tablets; Rx 50,000 IU capsules; liquid drops 400-2,000 IU/drop (1) · Tablet (15, 30, 60 mg); oral solution; combination products (with [[Acetaminophen|acetaminophen]] or ibuprofen). (1)

None (37) · 10 mg/d (1) · 360 mg/day (1) · No strict; Institute of Medicine UL 4,000 IU/d in adults for chronic use (1) · Not strictly fixed; long-term Upper Limit ~4,000 IU/d in adults (Institute of Medicine) (1)

None (37) · for severe malabsorption) (1) · IM (rare (1) · Oral (3) · PO (only formulation marketed in the US). (1)

None (37) · 30-60 min (immediate-release); 1-2 h (extended-release) (1) · 30–60 min (PO) (1) · Days to weeks to raise 25(OH)D; clinical effect on bone over months (1) · Weeks to raise 25(OH)D into reference range (1)

None (37) · 4–6 hours (1) · 6 h (immediate-release); ~11 h (extended-release) (1) · Long; fat-soluble storage in adipose (1) · Long; fat-soluble, stored in adipose (1)

None (37) · 11-13 h (immediate-release); 11-16 h (extended-release) (1) · 2.5–3 hours (1) · ~24 hours (parent); ~15 days (25(OH)D); 25(OH)D stores persist for months'"`UNIQ--ref-00000330-QINU`"' (1) · ~24 hours (parent); ~15 days (25(OH)D); tissue stores months (1)

None (37) · 80-90% oral (1) · ~50% (variable, CYP2D6-dependent for analgesic effect). (1) · ~75% (oral; absorption improved with fat-containing meal) (1) · ~75% (oral; fat-soluble, absorption requires intact biliary/lipid digestion)'"`UNIQ--ref-00000331-QINU`"' (1)

None (37) · Avoid; risk of neonatal opioid withdrawal with chronic use; UM-mother breastfeeding contraindicated. (1) · Category D'"`UNIQ--ref-0000006C-QINU`"' (1) · Safe at replacement doses; deficiency is itself a risk in pregnancy and lactation.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (2)

None (37) · OTC (low-dose) and [[USLegal:Prescription only|Rx-only]] (50,000 IU and concentrated solutions) in US (1) · OTC (most) and [[USLegal:Prescription only|Rx-only]] (50,000 IU) in US (1) · Schedule IV (US) (1) · US Schedule II (single-entity); Schedule III–V (combination products by content). (1)