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Drilldown: Medicines

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Medicines > classes : Analgesic or Classic Psychedelic or [[:Category:Cholesterol_absorption_inhibitors|Cholesterol absorption inhibitor]]

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generic:
Codeine (2)
brand:
None (74) · (multiple, generic dominant) (1) · Darvon (1) · Delysid (historical, Sandoz, withdrawn 1965) (1) · Demerol (1) · Dilaudid (1) · Dolophine (1) · Duragesic (1) · Nubain (1) · Nucynta (1) · Opana (1) · Stadol (1) · Suboxone (1) · Talwin (1) · Vicodin (1) · Zetia (1)
classes: (Click arrow to add another value)
mechanism:
5-HT2A agonist (26) · Potent 5-HT2A agonist (5) · LSD analogue; 5-HT2A agonist (4) · Mu-opioid receptor agonist (4) · Prodrug of LSD; 5-HT2A agonist (4) · Potent mu-opioid receptor agonist (3) · Contains LSA (2) · Contains mescaline (2)
uses:
None (87) · Mild to moderate pain; cough suppression (low-dose). (1) · '"`UNIQ--vote-0000044C-QINU`"', '"`UNIQ--vote-0000044D-QINU`"', '"`UNIQ--vote-0000044E-QINU`"', '"`UNIQ--vote-0000044F-QINU`"' (1)
starting dose:
None (87) · 10 mg PO once daily, with or without food (1) · Adult: 15–60 mg every 4 hours as needed. (1)
preparations:
None (87) · 10 mg tablet; also as fixed-dose combinations with simvastatin (Vytorin) and atorvastatin (Liptruzet, withdrawn US 2015 but generics exist) (1) · Tablet (15, 30, 60 mg); oral solution; combination products (with [[Acetaminophen|acetaminophen]] or ibuprofen). (1)
fda max:
None (87) · 10 mg/d (1) · 360 mg/day (1)
routes:
None (86) · Oral (2) · PO (only formulation marketed in the US). (1)
onset:
None (86) · 30–60 min (PO) (1) · 30–60 minutes (1) · LDL lowering within 2 weeks (1)
duration:
None (86) · 24 hours (1) · 4–6 hours (1) · 8–12 hours (1)
halflife:
None (86) · 2.5–3 hours (1) · 3–5 hours (1) · ~22 hours (parent + active glucuronide)'"`UNIQ--ref-00000450-QINU`"' (1)
bioavailability:
None (86) · 70–90% (oral) (1) · Variable (oral; rapidly conjugated to active glucuronide; food does not affect)'"`UNIQ--ref-00000451-QINU`"' (1) · ~50% (variable, CYP2D6-dependent for analgesic effect). (1)
pregnancy:
None (86) · Avoid; risk of neonatal opioid withdrawal with chronic use; UM-mother breastfeeding contraindicated. (1) · Limited data; generally avoided particularly in combination with statin.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1) · Not established (1)
legal:
None (86) · Schedule I (United States) (1) · US Schedule II (single-entity); Schedule III–V (combination products by content). (1) · [[USLegal:Prescription only|Rx-only]] in US (1)

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