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Drilldown: Medicines

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Medicines > classes : Analgesic or Classic Psychedelic or [[:Category:Expectorants|Expectorant]]

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generic:
Codeine (2)
brand:
None (74) · (multiple, generic dominant) (1) · Darvon (1) · Delysid (historical, Sandoz, withdrawn 1965) (1) · Demerol (1) · Dilaudid (1) · Duragesic (1) · Mucinex, Robitussin, Tussin (1) · Nubain (1) · Nucynta (1) · Opana (1) · Stadol (1) · Talwin (1) · Vicodin (1)
classes: (Click arrow to add another value)
mechanism:
5-HT2A agonist (26) · Potent 5-HT2A agonist (5) · LSD analogue; 5-HT2A agonist (4) · Mu-opioid receptor agonist (4) · Prodrug of LSD; 5-HT2A agonist (4) · Potent mu-opioid receptor agonist (3) · Contains LSA (2) · Contains mescaline (2)
uses:
None (85) · Mild to moderate pain; cough suppression (low-dose). (1) · '"`UNIQ--vote-0000104E-QINU`"', '"`UNIQ--vote-0000104F-QINU`"' (1)
starting dose:
None (85) · 200-400 mg PO q4h (IR); 600-1200 mg PO q12h (Mucinex 12-Hour ER) (1) · Adult: 15–60 mg every 4 hours as needed. (1)
preparations:
None (85) · 100, 200, 400 mg IR tablets; 600 mg, 1200 mg Mucinex ER tablets; many liquid formulations and combination products with dextromethorphan, pseudoephedrine, antihistamines (1) · Tablet (15, 30, 60 mg); oral solution; combination products (with [[Acetaminophen|acetaminophen]] or ibuprofen). (1)
fda max:
None (85) · 2.4 g/d (1) · 360 mg/day (1)
routes:
None (84) · Oral (2) · PO (only formulation marketed in the US). (1)
onset:
None (84) · 30 minutes (1) · 30–60 min (PO) (1) · 30–60 minutes (1)
duration:
None (84) · 4 hours (IR); 12 hours (ER) (1) · 4–6 hours (1) · 8–12 hours (1)
halflife:
None (84) · 2.5–3 hours (1) · 3–5 hours (1) · ~1 hour'"`UNIQ--ref-00001050-QINU`"' (1)
bioavailability:
None (84) · 70–90% (oral) (1) · High (oral)'"`UNIQ--ref-00001051-QINU`"' (1) · ~50% (variable, CYP2D6-dependent for analgesic effect). (1)
pregnancy:
None (84) · Avoid; risk of neonatal opioid withdrawal with chronic use; UM-mother breastfeeding contraindicated. (1) · Generally considered acceptable.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1) · Not established (1)
legal:
None (84) · OTC in US (1) · Schedule I (United States) (1) · US Schedule II (single-entity); Schedule III–V (combination products by content). (1)

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