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Medicines > classes : Analgesic or Classic Psychedelic or [[:Category:Progestins|Progestin (synthetic progestogen)]]

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generic:
Codeine (2)
brand:
None (74) · (multiple, generic dominant) (1) · Aygestin (5 mg, Rx); Camila, Errin, Heather, Jolivette, Nor-QD, Ortho Micronor, Sharobel (0.35 mg POPs); component of many COCs (1) · Darvon (1) · Delysid (historical, Sandoz, withdrawn 1965) (1) · Demerol (1) · Dilaudid (1) · Duragesic (1) · Nubain (1) · Nucynta (1) · Opana (1) · Stadol (1) · Talwin (1) · Vicodin (1)
classes: (Click arrow to add another value)
mechanism:
5-HT2A agonist (26) · Potent 5-HT2A agonist (5) · LSD analogue; 5-HT2A agonist (4) · Mu-opioid receptor agonist (4) · Prodrug of LSD; 5-HT2A agonist (4) · Potent mu-opioid receptor agonist (3) · Contains LSA (2) · Contains mescaline (2)
uses:
None (85) · Mild to moderate pain; cough suppression (low-dose). (1) · '"`UNIQ--vote-000013F0-QINU`"', '"`UNIQ--vote-000013F1-QINU`"', '"`UNIQ--vote-000013F2-QINU`"', '"`UNIQ--vote-000013F3-QINU`"', '"`UNIQ--vote-000013F4-QINU`"' (1)
starting dose:
None (85) · Adult: 15–60 mg every 4 hours as needed. (1) · POP: 0.35 mg PO daily continuously (no placebo week); high-dose 5 mg Aygestin for amenorrhea/endometriosis 5-10 mg/d (1)
preparations:
None (85) · 0.35 mg POP tablets; 5 mg tablets (Aygestin); component of COCs and combination HRT (1) · Tablet (15, 30, 60 mg); oral solution; combination products (with [[Acetaminophen|acetaminophen]] or ibuprofen). (1)
fda max:
None (85) · 360 mg/day (1) · Indication-specific (1)
routes:
None (84) · Oral (2) · PO (only formulation marketed in the US). (1)
onset:
None (84) · 30–60 min (PO) (1) · 30–60 minutes (1) · Contraception within 48 hours of starting (POP); endometrial effects days (1)
duration:
None (84) · 4–6 hours (1) · 8–12 hours (1) · ~24 hours per dose (strict timing required for POP — within 3-hour window each day) (1)
halflife:
None (84) · 2.5–3 hours (1) · 3–5 hours (1) · ~8 hours'"`UNIQ--ref-000013F5-QINU`"' (1)
bioavailability:
None (84) · 70–90% (oral) (1) · ~50% (variable, CYP2D6-dependent for analgesic effect). (1) · ~65% (oral)'"`UNIQ--ref-000013F6-QINU`"' (1)
pregnancy:
None (84) · Avoid; risk of neonatal opioid withdrawal with chronic use; UM-mother breastfeeding contraindicated. (1) · Contraindicated in known pregnancy (Aygestin); the 0.35 mg POP is not teratogenic and does not need to be discontinued before conception planning.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1) · Not established (1)
legal:
None (84) · Schedule I (United States) (1) · US Schedule II (single-entity); Schedule III–V (combination products by content). (1) · [[USLegal:Prescription only|Rx-only]] in US (note: norgestrel 0.075 mg POP is now OTC as Opill since 2023, but norethindrone POP remains Rx) (1)

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