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Drilldown: Medicines

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Medicines > classes : Analgesic or Classic Psychedelic or gut-restricted)]]

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generic:
Codeine (2)
brand:
None (74) · (multiple, generic dominant) (1) · Darvon (1) · Delysid (historical, Sandoz, withdrawn 1965) (1) · Demerol (1) · Dilaudid (1) · Dolophine (1) · Duragesic (1) · Imodium, Imodium A-D (1) · Nubain (1) · Nucynta (1) · Opana (1) · Stadol (1) · Suboxone (1) · Talwin (1) · Vicodin (1)
classes: (Click arrow to add another value)
mechanism:
5-HT2A agonist (26) · Potent 5-HT2A agonist (5) · LSD analogue; 5-HT2A agonist (4) · Mu-opioid receptor agonist (4) · Prodrug of LSD; 5-HT2A agonist (4) · Potent mu-opioid receptor agonist (3) · Contains LSA (2) · Contains mescaline (2)
uses:
None (87) · Mild to moderate pain; cough suppression (low-dose). (1) · '"`UNIQ--vote-00000FCF-QINU`"', '"`UNIQ--vote-00000FD0-QINU`"', '"`UNIQ--vote-00000FD1-QINU`"' (1)
starting dose:
None (87) · 4 mg PO initially, then 2 mg after each loose stool, '''not to exceed 16 mg/d''' (8 mg OTC); chronic-use lower (1) · Adult: 15–60 mg every 4 hours as needed. (1)
preparations:
None (87) · 2 mg capsules and tablets; 1 mg/5 mL oral solution; combined with simethicone (Imodium Multi-Symptom) (1) · Tablet (15, 30, 60 mg); oral solution; combination products (with [[Acetaminophen|acetaminophen]] or ibuprofen). (1)
fda max:
None (87) · 16 mg/d (8 mg/d OTC) (1) · 360 mg/day (1)
routes:
None (86) · Oral (2) · PO (only formulation marketed in the US). (1)
onset:
None (86) · 30-60 minutes (1) · 30–60 min (PO) (1) · 30–60 minutes (1)
duration:
None (86) · 4–6 hours (1) · 8-12 hours (1) · 8–12 hours (1)
halflife:
None (86) · 2.5–3 hours (1) · 3–5 hours (1) · ~9-14 hours'"`UNIQ--ref-00000FD2-QINU`"' (1)
bioavailability:
None (86) · 70–90% (oral) (1) · ~0.3% (oral; extensive first-pass via CYP3A4 and P-glycoprotein-mediated efflux at the intestinal and blood-brain barriers limit systemic and CNS exposure at therapeutic doses)'"`UNIQ--ref-00000FD3-QINU`"' (1) · ~50% (variable, CYP2D6-dependent for analgesic effect). (1)
pregnancy:
None (86) · Avoid; risk of neonatal opioid withdrawal with chronic use; UM-mother breastfeeding contraindicated. (1) · Generally considered acceptable when needed.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1) · Not established (1)
legal:
None (86) · OTC in US (1) · Schedule I (United States) (1) · US Schedule II (single-entity); Schedule III–V (combination products by content). (1)

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