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: Analgesic

or Daimonica

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Codeine (2)

None (31) · ''Brugmansia'' spp., Angel's trumpet, ''borrachero'', ''toé'' (1) · (multiple, generic dominant) (1) · Darvon (1) · Deadly nightshade (1) · Demerol (1) · Dilaudid (1) · Dolophine (1) · Duragesic (1) · Henbane, black henbane (1) · Mandrake (1) · Nubain (1) · Nucynta (1) · Opana (1) · Stadol (1) · Suboxone (1) · Talwin (1) · Vicodin (1)

5-HT2A agonist (15) · 5-HT2A agonist; 5-HT3 antagonist (1) · 5-HT2A agonist; minor psilocybin mushroom alkaloid (1) · 5-HT2A agonist; primarily auditory effects (1) · 5-HT2A agonist; sigma-1 agonist (1) · Kappa agonist; mu antagonist (1) · Kappa agonist; mu partial agonist (1) · Kappa agonist; mu partial agonist/antagonist (1) · Monoamine releasing agent; 5-HT2A agonist; MAO inhibitor (1) · Mu-opioid agonist; norepinephrine reuptake inhibitor (1) · Mu-opioid receptor agonist (4) · Mu-opioid receptor agonist; NMDA antagonist (1) · Mu-opioid receptor agonist; prodrug (metabolized to morphine) (1) · Mu-opioid receptor agonist; sodium channel blocker (1) · Mu/kappa/delta agonist; NMDA antagonist (1) · Partial mu-opioid agonist; kappa antagonist (1) · Phosphodiesterase inhibitor; calcium channel blocker (1) · Potent 5-HT2A agonist; sigma-1 agonist (1) · Potent mu-opioid receptor agonist (3) · Prodrug of 4-HO-DET; 5-HT2A agonist (1) · Prodrug of 4-HO-DiPT; 5-HT2A agonist (1) · Prodrug of 4-HO-MET; 5-HT2A agonist (1) · Prodrug of 4-HO-MiPT; 5-HT2A agonist (1) · Prodrug of psilocin; 5-HT2A agonist (1) · Prodrug; converted to [[Morphine|morphine]] by [[Enzyme:CYP2D6|CYP2D6]] for analgesic action. (1) · Tropane alkaloids: hyoscyamine (dominant; the racemic form is atropine), scopolamine. Competitive muscarinic antagonism. (1) · Tropane alkaloids: hyoscyamine, scopolamine, atropine, apoatropine. (1) · Tropane alkaloids: hyoscyamine, scopolamine, in higher seed concentrations than belladonna or datura. (1) · Tropane alkaloids: scopolamine (dominant), hyoscyamine, atropine. Competitive antagonism at muscarinic acetylcholine receptors. (1)

None (43) · Mild to moderate pain; cough suppression (low-dose). (1) · '"`UNIQ--vote-00000006-QINU`"' (1) · '"`UNIQ--vote-00000008-QINU`"', '"`UNIQ--vote-00000009-QINU`"' (3)

None (47) · Adult: 15–60 mg every 4 hours as needed. (1)

None (43) · Flowers or leaves infused or smoked. Highly variable potency; narrow toxic margin (1) · Leaves and seeds, traditionally smoked or infused. Possibly the original Pythia oracle plant (1) · Leaves, berries, root. Historically: belladonna cigarettes ("Asthmador") OTC in US until the 1970s (1) · Root, traditionally carved into ''mannikens'' or infused into wine (1) · Tablet (15, 30, 60 mg); oral solution; combination products (with [[Acetaminophen|acetaminophen]] or ibuprofen). (1)

None (47) · 360 mg/day (1)

None (43) · inhalation (2) · Oral (4) · PO (only formulation marketed in the US). (1) · topical (1)

None (47) · 30–60 min (PO) (1)

None (47) · 4–6 hours (1)

None (47) · 2.5–3 hours (1)

None (47) · ~50% (variable, CYP2D6-dependent for analgesic effect). (1)

None (47) · Avoid; risk of neonatal opioid withdrawal with chronic use; UM-mother breastfeeding contraindicated. (1)

None (46) · Plant unrestricted; pharmaceutical atropine Rx-only (1) · US Schedule II (single-entity); Schedule III–V (combination products by content). (1)