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Drilldown: Medicines

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Medicines > classes : Analgesic or Phenethylamine

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generic:
Codeine (2)
brand:
None (30) · (multiple, generic dominant) (1) · Darvon (1) · Demerol (1) · Dilaudid (1) · Dolophine (1) · Duragesic (1) · Nexus, Eroxan (historical, late-1980s through mid-1990s) (1) · Nubain (1) · Nucynta (1) · Opana (1) · Stadol (1) · Suboxone (1) · Talwin (1) · Vicodin (1)
classes: (Click arrow to add another value)
mechanism:
5-HT2A agonist (12) · 5-HT2A agonist; long duration (1) · 5-HT2A agonist; MAO inhibitor (1) · 5-HT2A agonist; milder than other 2C-x (1) · 5-HT2A partial agonist (1) · Extremely potent 5-HT2A agonist; vasoconstrictor (1) · Extremely potent 5-HT2A agonist; very long duration (1) · Kappa agonist; mu antagonist (1) · Kappa agonist; mu partial agonist (1) · Kappa agonist; mu partial agonist/antagonist (1) · Mu-opioid agonist; norepinephrine reuptake inhibitor (1) · Mu-opioid receptor agonist (4) · Mu-opioid receptor agonist; NMDA antagonist (1) · Mu-opioid receptor agonist; prodrug (metabolized to morphine) (1) · Mu-opioid receptor agonist; sodium channel blocker (1) · Mu/kappa/delta agonist; NMDA antagonist (1) · Partial mu-opioid agonist; kappa antagonist (1) · Phosphodiesterase inhibitor; calcium channel blocker (1) · Potent 5-HT2A agonist (5) · Potent 5-HT2A agonist; no oral activity (1) · Potent 5-HT2A agonist; very long duration (1) · Potent mu-opioid receptor agonist (3) · Prodrug; converted to [[Morphine|morphine]] by [[Enzyme:CYP2D6|CYP2D6]] for analgesic action. (1) · Very potent 5-HT2A agonist; long duration (1)
uses:
None (43) · Mild to moderate pain; cough suppression (low-dose). (1)
starting dose:
None (43) · Adult: 15–60 mg every 4 hours as needed. (1)
preparations:
None (43) · Tablet (15, 30, 60 mg); oral solution; combination products (with [[Acetaminophen|acetaminophen]] or ibuprofen). (1)
fda max:
None (43) · 360 mg/day (1)
routes:
None (42) · insufflated (1) · Oral (1) · PO (only formulation marketed in the US). (1) · PR (1)
onset:
None (42) · 30–60 min (PO) (1) · 45-75 min (oral) (1)
duration:
None (42) · 4-8 h (1) · 4–6 hours (1)
halflife:
None (42) · 2.5–3 hours (1) · Not well characterized (1)
bioavailability:
None (42) · Not well characterized (1) · ~50% (variable, CYP2D6-dependent for analgesic effect). (1)
pregnancy:
None (42) · Avoid; risk of neonatal opioid withdrawal with chronic use; UM-mother breastfeeding contraindicated. (1) · Not established (1)
legal:
None (42) · US Schedule II (single-entity); Schedule III–V (combination products by content). (1) · [[USLegal:DEA Schedule I|Schedule I]] (United States) (1)

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