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Drilldown: Medicines

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Medicines > classes : Analgesic or Stimulant or [[:Category:Diuretics|Diuretic]]

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generic:
Codeine (2)
brand:
None (47) · (multiple, generic dominant) (1) · Benzedrex (1) · Darvon (1) · Demerol (1) · Dilaudid (1) · Duragesic (1) · Lasix (1) · Nubain (1) · Nucynta (1) · Opana (1) · Stadol (1) · Talwin (1) · Vicodin (1)
classes: (Click arrow to add another value)
mechanism:
Monoamine releasing agent (8) · Dopamine/norepinephrine reuptake inhibitor (5) · Mu-opioid receptor agonist (4) · Potent mu-opioid receptor agonist (3) · Cathinone analogue; monoamine reuptake inhibitor (2) · Dopamine and norepinephrine reuptake inhibitor (2) · Norepinephrine–dopamine reuptake inhibitor (2)
uses:
None (58) · Mild to moderate pain; cough suppression (low-dose). (1) · '"`UNIQ--vote-0000021C-QINU`"', '"`UNIQ--vote-0000021D-QINU`"', '"`UNIQ--vote-0000021E-QINU`"', '"`UNIQ--vote-0000021F-QINU`"', '"`UNIQ--vote-00000220-QINU`"', '"`UNIQ--vote-00000221-QINU`"' (1)
starting dose:
None (58) · 20-40 mg PO/IV; titrate by clinical response. In diuretic-resistant heart failure or CKD, doses to 200 mg or higher may be needed (1) · Adult: 15–60 mg every 4 hours as needed. (1)
preparations:
None (58) · 20, 40, 80 mg tablets; 10 mg/mL oral solution; 10 mg/mL IV (1) · Tablet (15, 30, 60 mg); oral solution; combination products (with [[Acetaminophen|acetaminophen]] or ibuprofen). (1)
fda max:
None (58) · 360 mg/day (1) · 600 mg/d typical practical ceiling in heart failure (1)
routes:
None (58) · IM (1) · IV (1) · Oral (1) · PO (only formulation marketed in the US). (1)
onset:
None (58) · 30–60 min (PO) (1) · IV: 5 minutes; PO: 30-60 minutes (1)
duration:
None (58) · 4–6 hours (1) · IV: ~2 hours; PO: 6-8 hours (1)
halflife:
None (58) · 1.5-2 hours (longer in renal failure)'"`UNIQ--ref-00000222-QINU`"' (1) · 2.5–3 hours (1)
bioavailability:
None (58) · ~50% (oral; highly variable, 10-100%, hence the standard 1:2 IV-to-PO conversion)'"`UNIQ--ref-00000223-QINU`"' (1) · ~50% (variable, CYP2D6-dependent for analgesic effect). (1)
pregnancy:
None (58) · Avoid where possible; can reduce uteroplacental perfusion and produce neonatal electrolyte disturbance. Reserved for compelling indications.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1) · Avoid; risk of neonatal opioid withdrawal with chronic use; UM-mother breastfeeding contraindicated. (1)
legal:
None (58) · US Schedule II (single-entity); Schedule III–V (combination products by content). (1) · [[USLegal:Prescription only|Rx-only]] in US (1)

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