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Drilldown: Medicines

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Medicines > classes : Analgesic or Stimulant or [[:Category:Orexigenics|Appetite-promoting medicine (orexigenic)]]

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generic:
Codeine (2)
brand:
None (47) · (multiple, generic dominant) (1) · Benzedrex (1) · Darvon (1) · Demerol (1) · Dilaudid (1) · Dolophine (1) · Duragesic (1) · Nubain (1) · Nucynta (1) · Opana (1) · Periactin (US brand discontinued; generic widely available) (1) · Stadol (1) · Suboxone (1) · Talwin (1) · Vicodin (1)
classes: (Click arrow to add another value)
mechanism:
Monoamine releasing agent (8) · Dopamine/norepinephrine reuptake inhibitor (5) · Mu-opioid receptor agonist (4) · Potent mu-opioid receptor agonist (3) · Cathinone analogue; monoamine reuptake inhibitor (2) · Dopamine and norepinephrine reuptake inhibitor (2) · Norepinephrine–dopamine reuptake inhibitor (2)
uses:
None (60) · Mild to moderate pain; cough suppression (low-dose). (1) · '"`UNIQ--vote-00000019-QINU`"', '"`UNIQ--vote-0000001A-QINU`"', '"`UNIQ--vote-0000001B-QINU`"', '"`UNIQ--vote-0000001C-QINU`"', '"`UNIQ--vote-0000001D-QINU`"' (1)
starting dose:
None (60) · Adult: 15–60 mg every 4 hours as needed. (1) · Allergy: 4 mg PO TID. Serotonin syndrome: 12 mg loading dose PO or by nasogastric tube, then 2 mg every 2 hours until clinical improvement. Appetite stimulation: 2-4 mg PO TID-QID (1)
preparations:
None (60) · Tablet (15, 30, 60 mg); oral solution; combination products (with [[Acetaminophen|acetaminophen]] or ibuprofen). (1) · Tablets 4 mg; oral syrup 2 mg/5 mL (1)
fda max:
None (60) · 32 mg/day adult; weight-based pediatric ceiling (1) · 360 mg/day (1)
routes:
None (60) · Oral (1) · PO (only formulation marketed in the US). (1)
onset:
None (60) · 30-60 minutes (1) · 30–60 min (PO) (1)
duration:
None (60) · 4–6 hours (1) · 6-8 hours (1)
halflife:
None (60) · 2.5–3 hours (1) · 8-16 hours'"`UNIQ--ref-0000001E-QINU`"' (1)
bioavailability:
None (60) · ~50% (variable, CYP2D6-dependent for analgesic effect). (1) · ~95% (oral)'"`UNIQ--ref-0000001F-QINU`"' (1)
pregnancy:
None (60) · Avoid; risk of neonatal opioid withdrawal with chronic use; UM-mother breastfeeding contraindicated. (1) · Limited human data; older agent with substantial use experience.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
None (60) · US Schedule II (single-entity); Schedule III–V (combination products by content). (1) · [[USLegal:Prescription only|Rx-only]] in US (1)

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