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Drilldown: Medicines

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Medicines > classes : Anticonvulsant or D2/D3/5HT1A partial agonist or Opioid

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generic:
Codeine (2)
brand:
None (12)
classes: (Click arrow to add another value)
mechanism:
Potent mu-opioid receptor agonist (6) · Mu-opioid receptor agonist (4) · Sodium channel blocker (2)
uses:
None (50) · Mild to moderate pain; cough suppression (low-dose). (1) · Schizophrenia (FDA-approved 2015). Acute manic or mixed episodes of bipolar I disorder. Bipolar I depression (FDA-approved 2019). Adjunctive treatment of major depressive disorder (FDA-approved Dec 2022). (1)
starting dose:
None (50) · Adult: 15–60 mg every 4 hours as needed. (1) · Schizophrenia: 1.5 mg PO daily, increase to 1.5-6 mg as tolerated. Bipolar mania: 1.5 mg, may increase to 3-6 mg. Bipolar depression: 1.5 mg daily for 14 days, then 3 mg. MDD adjunct: 1.5 mg, may increase to 3 mg. (1)
preparations:
None (50) · 1.5 mg, 3 mg, 4.5 mg, 6 mg capsules (1) · Tablet (15, 30, 60 mg); oral solution; combination products (with [[Acetaminophen|acetaminophen]] or ibuprofen). (1)
fda max:
None (50) · 360 mg/day (1) · 6 mg/d (psychosis/mania); 3 mg/d (depression adjunct) (1)
routes:
None (50) · Oral (1) · PO (only formulation marketed in the US). (1)
onset:
None (50) · 30–60 min (PO) (1) · Weeks for psychosis/mood efficacy (1)
duration:
None (50) · 4–6 hours (1) · Daily dosing; active metabolites with very long half-lives (up to 1-3 weeks) (1)
halflife:
None (50) · 2.5–3 hours (1) · Cariprazine ~2-4 d; major active metabolites desmethyl-cariprazine (DCAR) ~1-3 weeks → 'oral depot' effect with delayed steady-state and reduced effect of missed doses (1)
bioavailability:
None (50) · Adequate oral bioavailability (1) · ~50% (variable, CYP2D6-dependent for analgesic effect). (1)
pregnancy:
None (50) · Avoid; risk of neonatal opioid withdrawal with chronic use; UM-mother breastfeeding contraindicated. (1) · Limited data (1)
legal:
None (50) · Rx (1) · US Schedule II (single-entity); Schedule III–V (combination products by content). (1)

Showing below up to 52 results in range #1 to #52.

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