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Medicines > classes : Antiparkinsonian or Opioid or non-selective)]]

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generic:
Codeine (2)
brand:
None (13) · (multiple, generic dominant) (1) · Advil, Motrin, IBU, Caldolor (IV), NeoProfen (neonatal IV) (1) · Akineton (1) · Alfenta (1) · Apokyn (1) · Artane (1) · Azilect (1) · Cogentin (1) · Comtan (1) · Darvon (1) · Demerol (1) · Dilaudid (1) · Dolophine (1) · Dostinex (1) · Duragesic (1) · Eldepryl (1) · Heroin (1) · Krokodil (1) · Neupro (1) · Nubain (1) · Nucynta (1) · O-DSMT (1) · Ongentys (1) · Opana (1) · Parlodel (1) · Sinemet (1) · Stablon (1) · Stadol (1) · Suboxone (1) · Sufenta (1) · Symmetrel (1) · Talwin (1) · Tasmar (1) · Ultiva (1) · Vicodin (1) · Xadago (1)
classes: (Click arrow to add another value)
mechanism:
Potent mu-opioid receptor agonist (6) · Mu-opioid receptor agonist (4) · Irreversible selective MAO-B inhibitor (2)
uses:
None (47) · Mild to moderate pain; cough suppression (low-dose). (1) · '"`UNIQ--vote-0000001F-QINU`"', '"`UNIQ--vote-00000020-QINU`"', '"`UNIQ--vote-00000021-QINU`"', '"`UNIQ--vote-00000022-QINU`"', '"`UNIQ--vote-00000023-QINU`"', '"`UNIQ--vote-00000024-QINU`"', '"`UNIQ--vote-00000025-QINU`"' (1)
starting dose:
None (47) · 200-400 mg PO every 4-6 hours as needed. OTC max 1200 mg/day without provider direction; prescription max 3200 mg/day divided (1) · Adult: 15–60 mg every 4 hours as needed. (1)
preparations:
None (47) · Tablet (15, 30, 60 mg); oral solution; combination products (with [[Acetaminophen|acetaminophen]] or ibuprofen). (1) · Tablets 200, 400, 600, 800 mg; capsules 200 mg; oral suspension 100 mg/5 mL; chewable tablets 100 mg; injection 100 mg/mL (Caldolor) (1)
fda max:
None (47) · 3200 mg/day (Rx); 1200 mg/day (OTC, without provider direction) (1) · 360 mg/day (1)
routes:
None (47) · intravenous (Caldolor (1) · NeoProfen) (1) · Oral (1) · PO (only formulation marketed in the US). (1)
onset:
None (47) · 30-60 minutes (oral) (1) · 30–60 min (PO) (1)
duration:
None (47) · 4-6 hours (1) · 4–6 hours (1)
halflife:
None (47) · 2-4 hours'"`UNIQ--ref-00000026-QINU`"' (1) · 2.5–3 hours (1)
bioavailability:
None (47) · ~50% (variable, CYP2D6-dependent for analgesic effect). (1) · ~80-100% (oral)'"`UNIQ--ref-00000027-QINU`"' (1)
pregnancy:
None (47) · Avoid from 20 weeks gestation onward per FDA's 2020 expanded NSAID warning (fetal renal dysfunction, oligohydramnios); contraindicated from 30 weeks (risk of premature ductus arteriosus closure)'"`UNIQ--ref-00000028-QINU`"' (1) · Avoid; risk of neonatal opioid withdrawal with chronic use; UM-mother breastfeeding contraindicated. (1)
legal:
None (47) · US Schedule II (single-entity); Schedule III–V (combination products by content). (1) · [[USLegal:Over-the-counter|OTC]] in the US at ≤200 mg per tablet / ≤1200 mg/day; [[USLegal:Prescription only|Rx-only]] at higher strengths and indications (1)

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