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Medicines > classes : Botanical or Opioid or [[GLP-1 receptor agonist]] · [[Antidiabetic medicines|Antidiabetic]] · Fc-fusion biologic

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generic:
Codeine (2)
brand:
None (32) · (multiple, generic dominant) (1) · Alfenta (1) · Darvon (1) · Demerol (1) · Dilaudid (1) · Duragesic (1) · Heroin (1) · Krokodil (1) · Nubain (1) · Nucynta (1) · O-DSMT (1) · Opana (1) · Stablon (1) · Stadol (1) · Sufenta (1) · Talwin (1) · Trulicity (1) · Ultiva (1) · Vicodin (1)
classes: (Click arrow to add another value)
mechanism:
Potent mu-opioid receptor agonist (6) · Mu-opioid receptor agonist (4) · Contains LSA (2) · Contains mescaline (2)
uses:
None (49) · Mild to moderate pain; cough suppression (low-dose). (1) · [[Type 2 diabetes mellitus]] · [[Cardiovascular risk reduction]] in T2DM (1)
starting dose:
None (49) · 0.75 mg SC weekly'"`UNIQ--ref-00000053-QINU`"' (1) · Adult: 15–60 mg every 4 hours as needed. (1)
preparations:
None (49) · Pre-filled single-dose pen: 0.75 / 1.5 / 3 / 4.5 mg'"`UNIQ--ref-00000054-QINU`"' (1) · Tablet (15, 30, 60 mg); oral solution; combination products (with [[Acetaminophen|acetaminophen]] or ibuprofen). (1)
fda max:
None (49) · 360 mg/day (1) · 4.5 mg/wk SC'"`UNIQ--ref-00000055-QINU`"' (1)
routes:
None (49) · PO (only formulation marketed in the US). (1) · Subcutaneous (abdomen (1) · thigh (1) · upper arm)'"`UNIQ--ref-00000056-QINU`"' (1)
onset:
None (49) · 30–60 min (PO) (1) · Glycemic effect within days; near-maximal HbA1c effect by 4 weeks at any given dose'"`UNIQ--ref-00000057-QINU`"' (1)
duration:
None (49) · 4–6 hours (1) · ~7 days (weekly dosing)'"`UNIQ--ref-00000058-QINU`"' (1)
halflife:
None (49) · 2.5–3 hours (1) · ~5 days (~120 h)'"`UNIQ--ref-00000059-QINU`"' (1)
bioavailability:
None (49) · SC ~47%–65%'"`UNIQ--ref-0000005A-QINU`"' (1) · ~50% (variable, CYP2D6-dependent for analgesic effect). (1)
pregnancy:
None (49) · Avoid. Discontinue at least 1 month before planned pregnancy. Animal data show embryofetal harm.'"`UNIQ--ref-0000005B-QINU`"' (1) · Avoid; risk of neonatal opioid withdrawal with chronic use; UM-mother breastfeeding contraindicated. (1)
legal:
None (49) · Rx-only;'"`UNIQ--ref-0000005C-QINU`"' not a controlled substance (1) · US Schedule II (single-entity); Schedule III–V (combination products by content). (1)

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