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Drilldown: Medicines

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Medicines > classes : Neuroleptic or Opioid or Phantastica

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generic:
Codeine (2)
brand:
None (12)
classes: (Click arrow to add another value)
mechanism:
Potent mu-opioid receptor agonist (6) · Mu-opioid receptor agonist (4) · Phenothiazine D2 antagonist (4)
uses:
None (47) · Mild to moderate pain; cough suppression (low-dose). (1) · '"`UNIQ--vote-00000006-QINU`"' (3) · '"`UNIQ--vote-00000008-QINU`"', '"`UNIQ--vote-00000009-QINU`"' (2)
starting dose:
None (52) · Adult: 15–60 mg every 4 hours as needed. (1)
preparations:
None (47) · Acid/base extraction of fresh young grass for tryptamines; combined with an MAOI (1) · Bark/woody stem decocted with a DMT-source plant (''Psychotria viridis'', ''Diplopterys cabrerana'') to make ayahuasca (1) · Bright red seeds, traditionally ingested or smoked. Highly toxic, narrow margin between active and lethal (1) · Parotid-gland venom expressed onto a glass plate, dried into a shellac-like resin, vaporized and inhaled (1) · Root bark acid/base-extracted for DMT; or as the resurrected ''jurema preta'' brew (decocted with an MAOI such as ''Peganum harmala'') (1) · Tablet (15, 30, 60 mg); oral solution; combination products (with [[Acetaminophen|acetaminophen]] or ibuprofen). (1)
fda max:
None (52) · 360 mg/day (1)
routes:
None (47) · Inhalation (vaporized) (1) · Oral (2) · Oral (with MAOI) (2) · PO (only formulation marketed in the US). (1) · smoked (extracted DMT) (1)
onset:
None (51) · 30–60 min (PO) (1) · Seconds (1)
duration:
None (51) · 4–6 hours (1) · ~15 min (1)
halflife:
None (52) · 2.5–3 hours (1)
bioavailability:
None (52) · ~50% (variable, CYP2D6-dependent for analgesic effect). (1)
pregnancy:
None (52) · Avoid; risk of neonatal opioid withdrawal with chronic use; UM-mother breastfeeding contraindicated. (1)
legal:
None (51) · 5-MeO-DMT is Schedule I in US (since 2011); the toad itself is protected in several southwestern states (1) · US Schedule II (single-entity); Schedule III–V (combination products by content). (1)

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