Drilldown: Medicines
Use the filters below to narrow your results.
generic:
brand:
classes:
Research material (131) ·
Classic Psychedelic (69) ·
Stimulant (43) ·
Opioid (31) ·
Sedative-Hypnotic (29) ·
Tryptamine (26) ·
Phenethylamine (25) ·
Botanical (23) ·
Benzodiazepine (22) ·
Anticonvulsant (19) ·
Dissociative (19) ·
Analgesic (17) ·
Antidepressant (17) ·
Antipsychotic (17) ·
Antiparkinsonian (16) ·
Empathogen (16) ·
Neuroleptic (16) ·
Plant Medicine (16) ·
Cathinone (14) ·
Nootropic (13)
mechanism:
5-HT2A agonist (27) ·
GABAA positive allosteric modulator (22) ·
None (18) ·
Monoamine releasing agent (11) ·
CB1/CB2 agonist (7) ·
Potent mu-opioid receptor agonist (6) ·
Sodium channel blocker (6) ·
Dopamine/norepinephrine reuptake inhibitor (5) ·
GABAA potentiator; NMDA antagonist (5) ·
Phenothiazine D2 antagonist (5) ·
Potent 5-HT2A agonist (5) ·
5-HT1B/1D agonist (4) ·
LSD analogue; 5-HT2A agonist (4) ·
Mu-opioid receptor agonist (4) ·
Muscarinic receptor antagonist (4) ·
Prodrug of LSD; 5-HT2A agonist (4) ·
Selective norepinephrine reuptake inhibitor (4)
uses:
None (395) ·
Antimanic, Antidepressive, Antisuicide (1) ·
Pain, cough, disquiet (1) ·
'"`UNIQ--vote-00000006-QINU`"' (3) ·
'"`UNIQ--vote-00000008-QINU`"', '"`UNIQ--vote-00000009-QINU`"' (7) ·
'"`UNIQ--vote-0000000C-QINU`"', '"`UNIQ--vote-0000000D-QINU`"', '"`UNIQ--vote-0000000E-QINU`"', '"`UNIQ--vote-0000000F-QINU`"' (1) ·
'"`UNIQ--vote-0000001B-QINU`"', '"`UNIQ--vote-0000001C-QINU`"', '"`UNIQ--vote-0000001D-QINU`"', '"`UNIQ--vote-0000001E-QINU`"', '"`UNIQ--vote-0000001F-QINU`"' (2) ·
'"`UNIQ--vote-0000001D-QINU`"', '"`UNIQ--vote-0000001E-QINU`"', '"`UNIQ--vote-0000001F-QINU`"', '"`UNIQ--vote-00000020-QINU`"', '"`UNIQ--vote-00000021-QINU`"', '"`UNIQ--vote-00000022-QINU`"' (1) ·
'"`UNIQ--vote-0000001F-QINU`"', '"`UNIQ--vote-00000020-QINU`"', '"`UNIQ--vote-00000021-QINU`"', '"`UNIQ--vote-00000022-QINU`"', '"`UNIQ--vote-00000023-QINU`"', '"`UNIQ--vote-00000024-QINU`"', '"`UNIQ--vote-00000025-QINU`"' (1) ·
'"`UNIQ--vote-00000021-QINU`"', '"`UNIQ--vote-00000022-QINU`"', '"`UNIQ--vote-00000023-QINU`"', '"`UNIQ--vote-00000024-QINU`"', '"`UNIQ--vote-00000025-QINU`"', '"`UNIQ--vote-00000026-QINU`"', '"`UNIQ--vote-00000027-QINU`"', '"`UNIQ--vote-00000028-QINU`"' (1) ·
'"`UNIQ--vote-00000065-QINU`"' (1) ·
'"`UNIQ--vote-000000AD-QINU`"', '"`UNIQ--vote-000000AE-QINU`"' (1) ·
'"`UNIQ--vote-000003A0-QINU`"', '"`UNIQ--vote-000003A1-QINU`"' (1) ·
'"`UNIQ--vote-000004B9-QINU`"', '"`UNIQ--vote-000004BA-QINU`"', '"`UNIQ--vote-000004BB-QINU`"' (1) ·
'"`UNIQ--vote-0000069B-QINU`"', '"`UNIQ--vote-0000069C-QINU`"' (1) ·
'"`UNIQ--vote-0000081E-QINU`"' (1) ·
'"`UNIQ--vote-0000099F-QINU`"', '"`UNIQ--vote-000009A0-QINU`"', '"`UNIQ--vote-000009A1-QINU`"', '"`UNIQ--vote-000009A2-QINU`"', '"`UNIQ--vote-000009A3-QINU`"', '"`UNIQ--vote-000009A4-QINU`"' (1) ·
'"`UNIQ--vote-000009DF-QINU`"', '"`UNIQ--vote-000009E0-QINU`"', '"`UNIQ--vote-000009E1-QINU`"', '"`UNIQ--vote-000009E2-QINU`"', '"`UNIQ--vote-000009E3-QINU`"' (1) ·
'"`UNIQ--vote-00000B81-QINU`"', '"`UNIQ--vote-00000B82-QINU`"', '"`UNIQ--vote-00000B83-QINU`"' (1) ·
'"`UNIQ--vote-00000CCA-QINU`"', '"`UNIQ--vote-00000CCB-QINU`"' (1)
starting dose:
None (412) ·
15 mg PO at bedtime, titrate to 30-45 mg/day after 1-2 weeks. '''Counterintuitive dose paradox''': lower doses (7.5-15 mg) are more sedating than higher doses because H1 antihistamine effect dominates at low dose (1) ·
300 mg PO BID, or 600 mg PO once daily, ×5-10 days; pediatric 14 mg/kg/d (1) ·
5 mg PO (1) ·
5-10 mg PO once daily (2.5 mg if on diuretic or in heart failure); titrate to 10-20 mg BID for HFrEF (1) ·
60 mg PO BID or 180 mg PO once daily (1) ·
A measured pour of absinthe diluted 5:1 with cold water over sugar (the louche ritual) (1) ·
Depression (rarely used now): 25-75 mg PO at bedtime, titrate to 150 mg/day. Neuropathic pain / migraine prophylaxis: 10-25 mg at bedtime, titrate by 10-25 mg weekly to 50-100 mg/day. Elderly: 10 mg at bedtime (Beers-list cautions apply) (1) ·
Depression: 25 mg PO TID-QID or 75 mg at bedtime, titrate to 75-150 mg/day. Neuropathic pain: 10-25 mg at bedtime, titrate to 50-100 mg/day. Elderly: 10 mg at bedtime (Beers-list cautions, though less than amitriptyline) (1) ·
Depression: 25-75 mg/day to start, titrate to 75-150 mg/day at bedtime. Insomnia (Silenor): 3 mg PO 30 minutes before bedtime, max 6 mg. Topical (Prudoxin): apply to affected area every 3-4 hours (1) ·
ICS Pulmicort Flexhaler 180-360 mcg BID; intranasal Rhinocort 64 mcg/spray, 1-2 sprays/nostril daily; Entocort EC 9 mg PO daily for active Crohn's; Symbicort 80/4.5 or 160/4.5 mcg, 2 puffs BID (1) ·
Osteoarthritis: 200 mg PO once daily or 100 mg BID. Rheumatoid arthritis: 100-200 mg PO BID. Acute pain: 400 mg loading, then 200 mg every 12 hours (1)
preparations:
None (397) ·
2.5, 5, 10, 20 mg tablets; 1 mg/mL oral solution (Epaned); 1.25 mg/mL IV (enalaprilat) (1) ·
30, 60, 180 mg tablets; 30 mg ODT; 6 mg/mL oral suspension; all OTC (1) ·
300 mg capsules; 125, 250 mg/5 mL suspension (1) ·
A ''betel quid'': areca nut slice + betel leaf + slaked lime (calcium hydroxide) ± tobacco ± spices, chewed (1) ·
Acid/base extraction of fresh young grass for tryptamines; combined with an MAOI (1) ·
Bark/woody stem decocted with a DMT-source plant (''Psychotria viridis'', ''Diplopterys cabrerana'') to make ayahuasca (1) ·
Bright red seeds, traditionally ingested or smoked. Highly toxic, narrow margin between active and lethal (1) ·
Capsules 10, 25, 50, 75 mg; oral solution 10 mg/5 mL (1) ·
Capsules 10, 25, 50, 75, 100, 150 mg; oral concentrate 10 mg/mL; Silenor tablets 3, 6 mg; topical cream 5% (Prudoxin, Zonalon) (1) ·
Capsules 50, 100, 200, 400 mg; Elyxyb oral solution 25 mg/mL (1) ·
Desoxyn 5 mg tabs (1) ·
Dried leaves and twigs, infused in a gourd (''mate'') and drunk through a metal straw (''bombilla'') (1) ·
Dried leaves; absinthe liqueur (120–160 proof, with hyssop, lemon balm, fennel, anise, sometimes Acorus calamus) (1) ·
Fermented and roasted seeds, ground. Mexican tradition: drunk with chili, cornmeal, achiote. European tradition: with sugar and milk (1) ·
Flowers or leaves infused or smoked. Highly variable potency; narrow toxic margin (1) ·
Fresh nuts chewed; also dried and powdered (1) ·
Leaves and seeds, traditionally smoked or infused. Possibly the original Pythia oracle plant (1) ·
Leaves chewed with a pinch of slaked lime (the lime converts cocaine HCl to freebase for buccal absorption); also drunk as tea (''mate de coca'') (1) ·
Leaves, berries, root. Historically: belladonna cigarettes ("Asthmador") OTC in US until the 1970s (1) ·
Pulmicort Flexhaler DPI 90, 180 mcg/dose; Pulmicort Respules 0.25, 0.5, 1 mg/2 mL nebulized; Rhinocort intranasal 32 mcg/spray; Entocort EC 3 mg capsules; Uceris 9 mg ER tablets and rectal foam (1) ·
Roasted seeds ground to powder, mixed with water; commercial syrups and energy drinks (1) ·
Root bark acid/base-extracted for DMT; or as the resurrected ''jurema preta'' brew (decocted with an MAOI such as ''Peganum harmala'') (1) ·
Root, traditionally carved into ''mannikens'' or infused into wine (1) ·
Tablets 10, 25, 50, 75, 100, 150 mg (1) ·
Tablets 7.5, 15, 30, 45 mg; orally disintegrating tablets (SolTab) 15, 30, 45 mg (1) ·
Toasted leaves and twigs decocted to a near-black concentrate (1)
fda max:
None (413) ·
150 mg/day; therapeutic plasma-level monitoring recommended (target 50-150 ng/mL window) (1) ·
180 mg/d (adults) (1) ·
25 mg/day (ADHD per Desoxyn label); 15 mg/day (obesity, short-term, per Desoxyn label) (1) ·
300 mg/day (depression, hospitalized); 150 mg/day outpatient; 6 mg/day for insomnia (1) ·
300 mg/day (historical hospitalized inpatient depression); 150 mg/day outpatient typical ceiling (1) ·
40 mg/d (1) ·
400 mg/day for chronic indications; higher for short-term acute pain (1) ·
45 mg/day (1) ·
600 mg/d (1) ·
ICS ~1280 mcg/d; intranasal 256 mcg/d; Entocort 9 mg/d standard (1)
routes:
None (397) ·
buccal); refined cocaine has its own profile (1) ·
inhalation (2) ·
Inhaled (1) ·
intranasal (1) ·
IV (1) ·
nebulized (1) ·
Oral (20) ·
Oral (buccal) (1) ·
oral (enteric-coated (1) ·
Oral (leaf (1) ·
Oral (prescribed) (1) ·
Oral (with MAOI) (2) ·
rectal foam) (1) ·
smoked (extracted DMT) (1) ·
topical (2)
onset:
None (414) ·
1-2 hours (1) ·
30-60 minutes (1) ·
BP effect 1 hour; max at 4-6 hours (1) ·
Hours (1) ·
Inhaled: bronchial effect 1-2 weeks; oral GI effect 1-2 weeks (1) ·
Pain and migraine prophylaxis effect 1-4 weeks; antidepressant effect 4-6 weeks (1) ·
Sleep effect from first dose; analgesic and migraine-prophylaxis effect 1-4 weeks; antidepressant effect 4-6 weeks (1) ·
Sleep effect from first dose; antidepressant effect over 1-4 weeks (2)
duration: (Click arrow to add another value)
halflife:
None (414) ·
18-44 hours'"`UNIQ--ref-00000020-QINU`"' (1) ·
20-40 hours'"`UNIQ--ref-00000023-QINU`"' (1) ·
Amitriptyline 10-50 hours (highly variable); nortriptyline active metabolite 18-44 hours'"`UNIQ--ref-00000026-QINU`"' (1) ·
~1.7 hours'"`UNIQ--ref-000009E4-QINU`"' (1) ·
~11 hours (enalaprilat, the active metabolite)'"`UNIQ--ref-00000B84-QINU`"' (1) ·
~11 hours'"`UNIQ--ref-00000029-QINU`"' (1) ·
~14 hours'"`UNIQ--ref-00000CCC-QINU`"' (1) ·
~15 hours (parent); nordoxepin active metabolite ~30 hours'"`UNIQ--ref-00000020-QINU`"' (1) ·
~2-3.6 hours (plasma)'"`UNIQ--ref-000009A5-QINU`"' (1)
bioavailability:
None (414) ·
16-21% capsule, 25% suspension (oral; iron and antacids reduce absorption substantially)'"`UNIQ--ref-000009E5-QINU`"' (1) ·
~30% (oral)'"`UNIQ--ref-00000021-QINU`"' (1) ·
~33% (oral; fruit juices including grapefruit, orange, and apple reduce absorption substantially via OATP1A2 inhibition — distinctive interaction not seen with most other H1s)'"`UNIQ--ref-00000CCD-QINU`"' (1) ·
~50% (oral)'"`UNIQ--ref-00000021-QINU`"' (1) ·
~50% (oral)'"`UNIQ--ref-00000027-QINU`"' (1) ·
~50% (oral; substantial first-pass)'"`UNIQ--ref-00000024-QINU`"' (1) ·
~6-13% inhaled lung deposition; ~10% oral (Entocort EC; extensive first-pass via CYP3A4 — this is the basis of the favorable hepatic-targeted local-effect profile in IBD)'"`UNIQ--ref-000009A6-QINU`"' (1) ·
~60% (oral; food does not affect absorption)'"`UNIQ--ref-00000B85-QINU`"' (1) ·
~99% (oral)'"`UNIQ--ref-0000002A-QINU`"' (1)
pregnancy:
None (413) ·
'''Contraindicated in pregnancy''' (all trimesters); fetal renal injury, oligohydramnios, skull hypoplasia, hypotension. Stop on detection'"`UNIQ--ref-00000B86-QINU`"' (1) ·
Avoid from 20 weeks gestation onward per FDA's 2020 expanded NSAID warning (fetal renal dysfunction, oligohydramnios); contraindicated from 30 weeks (risk of premature ductus arteriosus closure)'"`UNIQ--ref-0000002B-QINU`"' (1) ·
Category C (per Desoxyn label) (1) ·
Generally considered safe in pregnancy.<sup class="pcp-cn" title="This claim needs a citation.">[[[Pharmacopedia:Citation needed|citation needed]]]</sup> (1) ·
Generally considered safe; loratadine and cetirizine have more pregnancy data and are typically preferred.<sup class="pcp-cn" title="This claim needs a citation.">[[[Pharmacopedia:Citation needed|citation needed]]]</sup> (1) ·
Limited human data; some observational signals reassuring relative to other antidepressants.<sup class="pcp-cn" title="This claim needs a citation.">[[[Pharmacopedia:Citation needed|citation needed]]]</sup> (1) ·
Long the preferred ICS in pregnancy (Pulmicort) due to the most pregnancy data among the class.<sup class="pcp-cn" title="This claim needs a citation.">[[[Pharmacopedia:Citation needed|citation needed]]]</sup> (1) ·
Older agent with substantial use experience; observational signals not clearly causal.<sup class="pcp-cn" title="This claim needs a citation.">[[[Pharmacopedia:Citation needed|citation needed]]]</sup> (1) ·
TCA class signal; limited human data specific to doxepin.<sup class="pcp-cn" title="This claim needs a citation.">[[[Pharmacopedia:Citation needed|citation needed]]]</sup> (1) ·
TCA class signal; limited human data specific to nortriptyline.<sup class="pcp-cn" title="This claim needs a citation.">[[[Pharmacopedia:Citation needed|citation needed]]]</sup> (1)
legal:
None (410) ·
Currently legal in most jurisdictions with thujone limits (1) ·
Leaves legal in Bolivia, Peru, Colombia; cocaine internationally controlled (1) ·
OTC (intranasal Rhinocort Allergy) and [[USLegal:Prescription only|Rx-only]] (other forms) in US (1) ·
OTC in US (1) ·
Plant unrestricted; pharmaceutical atropine Rx-only (1) ·
Schedule II (1) ·
[[USLegal:Prescription only|Rx-only]] in US (3) ·
[[USLegal:Prescription only|Rx-only]] in US. Carries the antidepressant '''Boxed Warning''' for suicidality in children, adolescents, and young adults'"`UNIQ--ref-00000022-QINU`"' (2) ·
[[USLegal:Prescription only|Rx-only]] in US. Carries the antidepressant '''Boxed Warning''' for suicidality in children, adolescents, and young adults'"`UNIQ--ref-00000025-QINU`"' (1) ·
[[USLegal:Prescription only|Rx-only]] in US. Carries the antidepressant '''Boxed Warning''' for suicidality in children, adolescents, and young adults'"`UNIQ--ref-00000028-QINU`"' (1)
Showing below up to 250 results in range #1 to #250.
1
2
- 2-AI
- 2-FA
- 2-FDCK
- 2-FMA
- 25B-NBOH
- 25B-NBOMe
- 25C-NBOH
- 25C-NBOMe
- 25I-NBOH
- 25I-NBOMe
- 25N-NBOMe
- 2C-B-FLY
- 2C-C
- 2C-D
- 2C-E
- 2C-I
- 2C-P
- 2C-T-2
- 2C-T-7
3
4
- 4-AcO-DET
- 4-AcO-DiPT
- 4-AcO-DMT
- 4-AcO-MET
- 4-AcO-MiPT
- 4-FA
- 4-FMA
- 4-HO-DET
- 4-HO-DiPT
- 4-HO-DPT
- 4-HO-EPT
- 4-HO-MET
- 4-HO-MiPT
- 4-MeO-PCP
- 4F-EPH
- 4F-MPH
5
6
7
A
- Apomorphine
- Armodafinil
- Artemisia absinthium
- Asenapine
- Atogepant
- Atropa belladonna
- Atropine
- Ayahuasca
B
- Baeocystin
- Banisteriopsis caapi
- Benzocaine
- Benztropine
- Benzydamine
- Betel
- Biperiden
- Black Drink
- Blue lotus
- Brivaracetam
- Bromantane
- Bromazepam
- Bromo-DragonFLY
- Bromocriptine
- Brompheniramine
- Brugmansia
- Budesonide
- Bufotenin
- Bupivacaine
- Buprenorphine
- Butalbital
- Butorphanol
- Butylone
C
- Cabergoline
- Caffeine
- Calea zacatechichi
- Cannabidiol
- Carbidopa/levodopa
- Carfentanil
- Carisoprodol
- Cathinone
- CBG
- CBN
- Cefdinir
- Celecoxib
- Cenobamate
- Chlordiazepoxide
- Chloroform
- Chlorpheniramine
- Chlorpromazine
- Chlorzoxazone
- Chocolate
- Clobazam
- Clomipramine
- Clonazolam
- Clorazepate
- Clozapine
- Coca
- Cocaine
- Codeine
- Coluracetam
- Curare
- Cyclazodone
D
- Datura
- Delta-10-THC
- Delta-8-THC
- Deschloroetizolam
- Deschloroketamine
- Desflurane
- Desipramine
- Desomorphine
- Desoxypipradrol
- DET
- Dexmedetomidine
- Dextroamphetamine
- Dextromethorphan
- Dextropropoxyphene
- Dextrorphan
- Diacetylmorphine
- Diclazepam
- Diethyl ether
- Dihydrocodeine
- Dihydroergotamine
- Dimenhydrinate
- Diphenidine
- DiPT
E
- Eletriptan
- Enalapril
- Entacapone
- Ephedrine
- Ephenidine
- Ephylone
- EPT
- Ergotamine
- Escaline
- Eslicarbazepine
- Esmolol
- Estazolam
- Eszopiclone
- ETH-LAD
- Ethcathinone
- Ethchlorvynol
- Ethosuximide
- Ethylmorphine
- Ethylone
- Ethylphenidate
- Eticyclidine
- Etizolam
- Etomidate
F
- F-Phenibut
- Felbamate
- Fenethylline
- Fenfluramine
- Fentanyl
- Fexofenadine
- Flualprazolam
- Flubromazepam
- Flubromazolam
- Flunitrazepam
- Flunitrazolam
- Fluphenazine
- Flurazepam
- Fosphenytoin
- Frovatriptan
G
H
- Halothane
- Harmaline
- Harmine
- Hawaiian Baby Woodrose
- Hexedrone
- HHC
- Hydrocodone
- Hydromorphone
- Hyoscyamine
- Hyoscyamus niger