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Medicines > uses : Acute treatment of migraine with or without aura in adults or Preventive treatment of migraine in adults (episodic and chronic) or None

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generic:
None (3)
 
brand:
None (237)
classes:
Research material (131) · Classic Psychedelic (70) · Stimulant (43) · Opioid (31) · Sedative-hypnotic (29) · Phenethylamine (26) · Tryptamine (26) · Botanical (23) · Benzodiazepine (22) · Anticonvulsant (19) · Dissociative (19) · Antidepressant (18) · Analgesic (17) · Antipsychotic (17) · Antiparkinsonian (16) · Empathogen (16) · Neuroleptic (16) · Cathinone (14) · Lysergamide (13) · Nootropic (13)
mechanism:
5-HT2A agonist (27) · GABAA positive allosteric modulator (22) · None (11) · Monoamine releasing agent (11) · CB1/CB2 agonist (7) · Potent mu-opioid receptor agonist (6) · Sodium channel blocker (6) · Dopamine/norepinephrine reuptake inhibitor (5) · GABAA potentiator; NMDA antagonist (5) · Phenothiazine D2 antagonist (5) · Potent 5-HT2A agonist (5) · 5-HT1B/1D agonist (4) · LSD analogue; 5-HT2A agonist (4) · Mu-opioid receptor agonist (4) · Muscarinic receptor antagonist (4) · Prodrug of LSD; 5-HT2A agonist (4) · Selective norepinephrine reuptake inhibitor (4)
 
uses: (Click arrow to add another value)
starting dose:
None (398) · 10 mg (one spray) intranasally in one nostril (1) · 225 mg SC monthly, or 675 mg SC every 3 months (quarterly) (1) · 25 mg (1) · 40 mg SC every other week (most adult indications); IBD induction 160 mg week 0, 80 mg week 2, then 40 mg every other week (1) · 70 mg SC monthly; may increase to 140 mg monthly (1)
preparations:
None (398) · 10 mg/spray nasal solution (1) · 225 mg/1.5 mL prefilled syringe or autoinjector (1) · 25 mg, 50 mg, 100 mg tablets; oral concentrate 20 mg/mL (1) · 40 mg/0.4 mL or 40 mg/0.8 mL prefilled syringe and autoinjector pen; 10, 20, 80 mg pediatric/induction strengths (1) · 70 mg/mL or 140 mg/mL prefilled autoinjector (1)
fda max:
None (398) · 10 mg per 24 h (1) · 140 mg/month (1) · 200 mg/d (1) · 40 mg every week (selected indications); otherwise 40 mg every other week (1) · 675 mg/quarter (1)
routes:
None (396) · insufflated (1) · Intranasal (1) · Oral (3) · PR (1) · Subcutaneous (3)
onset:
None (396) · 30–60 minutes (1) · 45-75 min (oral) (1) · Anxiolysis classically 3-4 weeks, continuing improvement to 8-12 weeks (1) · Onset of preventive effect over weeks; some patients respond after first dose (1) · Over weeks (1) · Pain relief reported within 15 min in trials (1) · Symptomatic effect within weeks; full response by 12-24 weeks (1)
duration:
None (395) · 2 weeks per dose (1) · 4-8 h (1) · 8–12 hours (1) · About 20 minutes (1) · Long (1) · Monthly dosing (1) · Monthly or quarterly dosing (1) · ~48 h sustained pain freedom in responders (1)
halflife:
None (395) · 3–5 hours (1) · 9–12 minutes (intravenous) (1) · Not well characterized (1) · ~14 days'"`UNIQ--ref-00001103-QINU`"' (1) · ~26 h (sertraline; range 13-45 h, longer in females); ~62-104 h (N-desmethylsertraline, weakly active) (1) · ~28 days (1) · ~31 days (1) · ~6.6 h (1)
bioavailability:
None (396) · 70–90% (oral) (1) · Absolute bioavailability not precisely characterized; food modestly increases exposure (1) · Not formally established (1) · Not well characterized (1) · ~5% intranasal (1) · ~64% from SC depot'"`UNIQ--ref-00001104-QINU`"' (1) · ~82% SC (1)
pregnancy:
None (397) · Category C'"`UNIQ--ref-0000008F-QINU`"' (1) · Limited data; avoid (3) · Not established (2)
legal:
None (396) · Rx (3) · Rx-only in US (1) · Schedule I (United States) (1) · [[USLegal:DEA Schedule I|Schedule I]] (United States) (2)

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